Cited 24 times in
Phospholipase C-delta1 rescues intracellular Ca2+ overload in ischemic heart and hypoxic neonatal cardiomyocytes
DC Field | Value | Language |
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dc.contributor.author | 권혁문 | - |
dc.date.accessioned | 2015-07-14T16:50:21Z | - |
dc.date.available | 2015-07-14T16:50:21Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0960-0760 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111692 | - |
dc.description.abstract | Ischemia and simulated ischemic conditions cause intracellular Ca2+ overload in the myocardium. The relationship between ischemia injury and Ca2+ overload has not been fully characterized. The aim of the present study was to investigate the expression and characteristics of PLC isozymes in myocardial infarction-induced cardiac remodeling and heart failure. In normal rat heart tissue, PLC-delta1 (about 44 ng/mg of heart tissue) was most abundant isozymes compared to PLC-gamma1 (6.8 ng/mg) and PLC-beta1 (0.4 ng/mg). In ischemic heart and hypoxic neonatal cardiomyocytes, PLC-delta1, but not PLC-beta1 and PLC-gamma1, was selectively degraded, a response that could be inhibited by the calpain inhibitor, calpastatin, and by the caspase inhibitor, zVAD-fmk. Overexpression of the PLC-delta1 in hypoxic neonatal cardiomyocytes rescued intracellular Ca2+ overload by ischemic conditions. In the border zone and scar region of infarcted myocardium, and in hypoxic neonatal cardiomyocytes, the selective degradation of PLC-delta1 by the calcium sensitive proteases may play important roles in intracellular Ca2+ regulations under the ischemic conditions. It is suggested that PLC isozyme-changes may contribute to the alterations in calcium homeostasis in myocardial ischemia. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 131~138 | - |
dc.relation.isPartOf | JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Phospholipase C-delta1 rescues intracellular Ca2+ overload in ischemic heart and hypoxic neonatal cardiomyocytes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.contributor.googleauthor | Soyeon Lim | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Sue Goo Rhee | - |
dc.contributor.googleauthor | Robert M. Graham | - |
dc.contributor.googleauthor | Kwang-Hoe Chung | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.contributor.googleauthor | Yun Soo Bae | - |
dc.contributor.googleauthor | Hyuck Moon Kwon | - |
dc.identifier.doi | 10.1016/j.jsbmb.2004.02.009 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J01757 | - |
dc.identifier.eissn | 1879-1220 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0960076004002249 | - |
dc.subject.keyword | Phospholipase C-δ1 | - |
dc.subject.keyword | Ischemic heart | - |
dc.subject.keyword | Hypoxic neonatal cardiomyocytes | - |
dc.contributor.alternativeName | Kwon, Hyuck Moon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 91 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 131 | - |
dc.citation.endPage | 138 | - |
dc.identifier.bibliographicCitation | JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, Vol.91(3) : 131-138, 2004 | - |
dc.identifier.rimsid | 37417 | - |
dc.type.rims | ART | - |
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