Cited 65 times in
Abrogation of cisplatin-induced hepatotoxicity in mice by xanthorrhizol is related to its effect on the regulation of gene transcription
DC Field | Value | Language |
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dc.contributor.author | 박광균 | - |
dc.contributor.author | 정원윤 | - |
dc.date.accessioned | 2015-07-14T16:47:47Z | - |
dc.date.available | 2015-07-14T16:47:47Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0041-008X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111606 | - |
dc.description.abstract | Cisplatin is a widely used anticancer drug, but at high dose, it can produce undesirable side effects such as hepatotoxicity. Because Curcuma xanthorrhiza Roxb. (Zingiberaceae) has been traditionally used to treat liver disorders, the protective effect of xanthorrhizol, which is isolated from C. xanthorrhiza, on cisplatin-induced hepatotoxicity was evaluated in mice. The pretreatment of xanthorrhizol (200 mg/kg/day, po) for 4 days prevented the hepatotoxicity induced by cisplatin (45 mg/kg, ip) with statistical significance. Interestingly, it abrogated cisplatin-induced DNA-binding activity of nuclear factor-kappaB (NF-κB), which consequently affected mRNA expression levels of NF-κB-dependent genes, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2), even in part. It also attenuated the cisplatin-suppressed DNA-binding activity of activator protein 1 (AP-1). Using differential display reverse transcription-polymerase chain reaction (DDRT-PCR), seven upregulated genes including S100 calcium binding protein A9 (S100A9) mRNA and antigenic determinant for rec-A protein mRNA and five downregulated genes including caseinolytic protease X (ClpX) mRNA and ceruloplasmin (CP) mRNA by cisplatin were identified. Although these mRNA expression patterns were not totally consistent with gel shift patterns, altered expression levels by cisplatin were reversed by the pretreatment of xanthorrhizol. In conclusion, the ability of xanthorrhizol to regulate the DNA-binding activities of transcription factors, NF-κB and AP-1, could be one possible mechanism to elucidate the preventive effect of xanthorrhizol on cisplatin-induced hepatotoxicity. Furthermore, genes identified in this study could be helpful to understand the mechanism of cisplatin-induced hepatotoxicity. Finally, the combination treatment of xanthorrhizol and cisplatin may provide more advantage than single treatment of cisplatin in cancer therapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 346~355 | - |
dc.relation.isPartOf | TOXICOLOGY AND APPLIED PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Alanine Transaminase/metabolism | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antineoplastic Agents/antagonists & inhibitors | - |
dc.subject.MESH | Antineoplastic Agents/toxicity* | - |
dc.subject.MESH | Aspartate Aminotransferases/metabolism | - |
dc.subject.MESH | Chemical and Drug Induced Liver Injury/enzymology | - |
dc.subject.MESH | Chemical and Drug Induced Liver Injury/prevention & control* | - |
dc.subject.MESH | Cisplatin/antagonists & inhibitors | - |
dc.subject.MESH | Cisplatin/toxicity* | - |
dc.subject.MESH | Cyclooxygenase 2 | - |
dc.subject.MESH | Gene Expression Regulation/drug effects | - |
dc.subject.MESH | Isoenzymes/drug effects | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | NF-kappa B/drug effects | - |
dc.subject.MESH | NF-kappa B/metabolism | - |
dc.subject.MESH | Phenols/therapeutic use* | - |
dc.subject.MESH | Prostaglandin-Endoperoxide Synthases/drug effects | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Transcription, Genetic | - |
dc.subject.MESH | gamma-Glutamyltransferase/metabolism | - |
dc.title | Abrogation of cisplatin-induced hepatotoxicity in mice by xanthorrhizol is related to its effect on the regulation of gene transcription | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Seong Hwan Kim | - |
dc.contributor.googleauthor | Kyoung Ok Hong | - |
dc.contributor.googleauthor | Kwang-Kyun Park | - |
dc.contributor.googleauthor | Jae Kwan Hwang | - |
dc.contributor.googleauthor | Won-Yoon Chung | - |
dc.identifier.doi | 10.1016/j.taap.2004.01.002 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J02742 | - |
dc.identifier.eissn | 1096-0333 | - |
dc.identifier.pmid | 15094305 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0041008X04000225 | - |
dc.subject.keyword | Xanthorrhizol | - |
dc.subject.keyword | Cisplatin | - |
dc.subject.keyword | Hepatotoxicity | - |
dc.subject.keyword | NF-κB | - |
dc.subject.keyword | AP-1 | - |
dc.subject.keyword | COX-2 | - |
dc.subject.keyword | Inos | - |
dc.subject.keyword | Differential display | - |
dc.contributor.alternativeName | Park, Kwang Kyun | - |
dc.contributor.alternativeName | Chung, Won Yoon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 196 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 346 | - |
dc.citation.endPage | 355 | - |
dc.identifier.bibliographicCitation | TOXICOLOGY AND APPLIED PHARMACOLOGY, Vol.196(3) : 346-355, 2004 | - |
dc.identifier.rimsid | 37360 | - |
dc.type.rims | ART | - |
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