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Proliferation of DU145 prostate cancer cells is inhibited by suppressing insulin-like growth factor binding protein-2
DC Field | Value | Language |
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dc.contributor.author | 박은성 | - |
dc.date.accessioned | 2015-07-14T16:41:01Z | - |
dc.date.available | 2015-07-14T16:41:01Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0919-8172 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/111380 | - |
dc.description.abstract | BACKGROUND: Insulin-like growth factor binding protein-2 (IGFBP-2) is expressed by all human prostate cancer cell lines and dramatically increases in the serum of prostate cancer patients. However, the role of IGFBP-2 in prostatic tumorigenesis is not known. The aim of the present study was to investigate the effects of IGFBP-2 on the proliferation of DU145 human prostate cancer cells in culture. METHODS: Using cell proliferation assays, we examined the effects of exogenously administered and endogenously modulated levels of IGFBP-2 on the proliferation of DU145 cells. RESULT: Cell growth was stimulated by exogenously administered IGFBP-2, but significantly retarded (P < 0.05) by its neutralizing antibody. Overexpression of IGFBP-2 by transfection also stimulated cell growth, which was significantly (P < 0.05) inhibited in transfectants expressing antisense mRNA to IGFBP-2. Furthermore, the proliferation of IGFBP-2 overexpressing cells was significantly dampened by exogenously administered IGFBP-2 antibody. CONCLUSIONS: IGFBP-2 is an autocrine growth factor for DU145 human prostate cancer cells and cell proliferation can be significantly retarded by neutralizing or inhibiting its synthesis. These findings provide a strong rationale for targeting IGFBP-2 in the testing of novel strategies to treat prostate cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 876~884 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF UROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Proliferation of DU145 prostate cancer cells is inhibited by suppressing insulin-like growth factor binding protein-2 | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Institute for Medical Convergence (연의-생공연 메디컬융합연구소) | - |
dc.contributor.googleauthor | SHILLA CHATTERJEE | - |
dc.contributor.googleauthor | EUN SUNG PARK | - |
dc.contributor.googleauthor | MELVYN S. SOLOFF | - |
dc.identifier.doi | 10.1111/j.1442-2042.2004.00898.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.relation.journalcode | J01169 | - |
dc.identifier.eissn | 1442-2042 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1442-2042.2004.00898.x/abstract | - |
dc.subject.keyword | IGFBP‐2 suppression | - |
dc.subject.keyword | growth inhibition | - |
dc.subject.keyword | prostate cancer. | - |
dc.contributor.alternativeName | Park, Eun Sung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 11 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 876 | - |
dc.citation.endPage | 884 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF UROLOGY, Vol.11(10) : 876-884, 2004 | - |
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