Cited 55 times in
Non-dippers are associated with adverse cardiac remodeling and dysfunction (R1)
DC Field | Value | Language |
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dc.contributor.author | 최동훈 | - |
dc.contributor.author | 최의영 | - |
dc.contributor.author | 하종원 | - |
dc.contributor.author | 고영국 | - |
dc.contributor.author | 박성하 | - |
dc.contributor.author | 임세중 | - |
dc.contributor.author | 정남식 | - |
dc.date.accessioned | 2015-06-10T13:02:10Z | - |
dc.date.available | 2015-06-10T13:02:10Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0167-5273 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/110890 | - |
dc.description.abstract | BACKGROUND: Non-dippers are known to carry a high risk of cardiovascular complications due to higher cumulative 24-h pressure load over time. In this study, we hypothesized that non-dippers would be associated with adverse cardiac remodeling and left ventricular (LV) dysfunction in treated hypertensive patients. MATERIALS AND METHODS: A total of 150 outpatients treated with antihypertensive drugs for at least 1 year were enrolled. The patients were classified as non-dippers if their daytime ambulatory systolic and diastolic BP did not decrease by at least 10% during the night. LV diastolic function was assessed by measuring mitral inflow velocity (E), early diastolic mitral annulus tissue velocity (E') and LV systolic function was assessed by measuring systolic tissue velocity (S'), longitudinal systolic strain and strain rate. RESULTS: The Cornell voltage product, LA volume index and LV mass index was significantly higher in non-dippers. Early diastolic mitral annulus tissue velocity (E') was lower and E/E' was higher in non-dippers suggestive of diastolic dysfunction. Systolic tissue velocity (S'), systolic strain and strain rate were significantly lower in non-dippers suggestive of systolic dysfunction. The non-dipper status, controlled for age, sex and LV mass index showed significant correlation with E' (beta=-0.203, P=0.002), E/E' (beta=0.354, P<0.001), S' (beta=-0.231, P=0.002), strain (beta=-0.162, P=0.040) and strain rate (beta=-0.186, P=0.015). CONCLUSIONS: This study showed the non-dippers in treated hypertensive patients were associated with adverse cardiac remodeling and early LV dysfunction. Further studies to demonstrate the long term prognostic significance of this finding is warranted. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 171~177 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Antihypertensive Agents/therapeutic use | - |
dc.subject.MESH | Blood Flow Velocity | - |
dc.subject.MESH | Blood Pressure/physiology* | - |
dc.subject.MESH | Blood Pressure Monitoring, Ambulatory | - |
dc.subject.MESH | Coronary Vessels/diagnostic imaging | - |
dc.subject.MESH | Diastole/physiology | - |
dc.subject.MESH | Echocardiography, Doppler | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mitral Valve/diagnostic imaging | - |
dc.subject.MESH | Systole/physiology | - |
dc.subject.MESH | Ventricular Dysfunction, Left/physiopathology* | - |
dc.subject.MESH | Ventricular Remodeling/physiology* | - |
dc.title | Non-dippers are associated with adverse cardiac remodeling and dysfunction (R1) | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hye-Sun Seo | - |
dc.contributor.googleauthor | Tae Soo Kang | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Eui Young Choi | - |
dc.contributor.googleauthor | Young-Guk Ko | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Jongwon Ha | - |
dc.contributor.googleauthor | Se-Joong Rim | - |
dc.contributor.googleauthor | Namsik Chung | - |
dc.identifier.doi | 10.1016/j.ijcard.2005.08.038 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A04165 | - |
dc.contributor.localId | A04257 | - |
dc.contributor.localId | A00127 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A03372 | - |
dc.contributor.localId | A03585 | - |
dc.relation.journalcode | J01093 | - |
dc.identifier.eissn | 1874-1754 | - |
dc.identifier.pmid | 16316694 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S016752730501171X | - |
dc.subject.keyword | Non-dippers | - |
dc.subject.keyword | Ambulatory blood pressure | - |
dc.subject.keyword | Cardiac remodeling | - |
dc.subject.keyword | LV dysfunction | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.alternativeName | Choi, Eui Young | - |
dc.contributor.alternativeName | Ha, Jong Won | - |
dc.contributor.alternativeName | Ko, Young Guk | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.alternativeName | Rim, Se Joong | - |
dc.contributor.alternativeName | Chung, Nam Sik | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Choi, Eui Young | - |
dc.contributor.affiliatedAuthor | Ha, Jong Won | - |
dc.contributor.affiliatedAuthor | Ko, Young Guk | - |
dc.contributor.affiliatedAuthor | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Rim, Se Joong | - |
dc.contributor.affiliatedAuthor | Chung, Nam Sik | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 112 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 171 | - |
dc.citation.endPage | 177 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.112(2) : 171-177, 2006 | - |
dc.identifier.rimsid | 54932 | - |
dc.type.rims | ART | - |
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