Cited 63 times in
Effects on weight reduction and safety of short-term phentermine administration in Korean obese people
DC Field | Value | Language |
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dc.contributor.author | 강희철 | - |
dc.contributor.author | 윤방부 | - |
dc.date.accessioned | 2015-06-10T12:43:24Z | - |
dc.date.available | 2015-06-10T12:43:24Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/110330 | - |
dc.description.abstract | The phentermine, an appetite suppressant, has been widely applied in Korea since 2004. However, there have been relatively few reports about the efficacy and the safety of phentermine in Korea. The aim of this study is to verify the effect of phentermine on weight reduction and the safety in Korean patients. This randomized, double-blind, placebo-controlled study had been performed between February and July, 2005, in Seoul on 68 relatively healthy obese adults whose body mass index was 25 kg/m2 or greater. They received phentermine-HCl 37.5 mg or placebo once daily with behavioral therapy for obesity. The primary endpoints were the changes of body weight and waist circumference from the baseline in the intention-to-treat population. Mean decrease of both body weight and waist circumference in phentermine-treated subjects were significantly greater than that of placebo group (weight: -6.7 ± 2.5 kg, p < 0.001; waist circumference: -6.2 ± 3.5 cm, p < 0.001). Significant number of subjects in phentermine group accomplished weight reduction of 5% or greater from the baseline and 10% or more (p < 0.001). There were no significant differences in systolic and diastolic blood pressure between the groups (p = 0.122 for systolic BP; p = 0.219 for diastolic BP). Dry mouth and insomnia were the only statistically significant adverse events that occurred more frequently in phentermine group. Most side effects of phentermine were mild to moderate in intensity. Short-term phentermine administration induced significant weight reduction and reduction of waist circumference without clinically problematic adverse events on relatively healthy Korean obese people. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 614~625 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Appetite Depressants/administration & dosage | - |
dc.subject.MESH | Appetite Depressants/adverse effects | - |
dc.subject.MESH | Appetite Depressants/therapeutic use* | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Obesity/drug therapy* | - |
dc.subject.MESH | Phentermine/administration & dosage | - |
dc.subject.MESH | Phentermine/adverse effects | - |
dc.subject.MESH | Phentermine/therapeutic use* | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Weight Loss/drug effects* | - |
dc.title | Effects on weight reduction and safety of short-term phentermine administration in Korean obese people | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학) | - |
dc.contributor.googleauthor | Kyoung Kon Kim | - |
dc.contributor.googleauthor | Hi-Jung Cho | - |
dc.contributor.googleauthor | Hee-Cheol Kang | - |
dc.contributor.googleauthor | Bang-Bu Youn | - |
dc.contributor.googleauthor | Kyu-Rae Lee | - |
dc.identifier.doi | 10.3349/ymj.2006.47.5.614 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00105 | - |
dc.contributor.localId | A02552 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 17066505 | - |
dc.subject.keyword | Obesity | - |
dc.subject.keyword | phentermine | - |
dc.subject.keyword | treatment outcome | - |
dc.contributor.alternativeName | Kang, Hee Cheol | - |
dc.contributor.alternativeName | Youn, Bang Bu | - |
dc.contributor.affiliatedAuthor | Kang, Hee Cheol | - |
dc.contributor.affiliatedAuthor | Youn, Bang Bu | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 47 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 614 | - |
dc.citation.endPage | 625 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.47(5) : 614-625, 2006 | - |
dc.identifier.rimsid | 38720 | - |
dc.type.rims | ART | - |
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