Antiangiogenic activity of deoxoartemisinin derivatives on chorioallantoic membrane

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Citation: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol.16(5) : 1227-1230, 2006

MeSH: Acetals/chemistry ; Angiogenesis Inhibitors/chemical synthesis* ; Angiogenesis Inhibitors/chemistry ; Angiogenesis Inhibitors/pharmacology* ; Animals ; Artemisinins/chemical synthesis ; Artemisinins/chemistry* ; Artemisinins/pharmacology* ; Chick Embryo ; Chorioallantoic Membrane/blood supply* ; Chorioallantoic Membrane/drug effects* ; Molecular Structure ; Sesquiterpenes/chemical synthesis ; Sesquiterpenes/chemistry* ; Sesquiterpenes/pharmacology* ; Structure-Activity Relationship

Abstract: Non acetal-type derivatives at C-12 of artemisinin and their novel dimers including a fullerene conjugate were synthesized and some of them showed potent in vivo antiangiogenic activity on chorioallantoic membrane higher than or comparable to those of fumagillin and thalidomide.

Full Text: http://www.sciencedirect.com/science/article/pii/S0960894X05015039

Appears in Collections:: 2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

Yonsei Authors: Park, Kwang Kyun(박광균)
Chung, Won Yoon(정원윤) https://orcid.org/0000-0001-8428-9005

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YUHSpace: Antiangiogenic activity of deoxoartemisinin derivatives on chorioallantoic membrane