Cited 43 times in
An interaction between the serotonin transporter promoter region and dopamine transporter polymorphisms contributes to harm avoidance and reward dependence traits in normal healthy subjects
DC Field | Value | Language |
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dc.contributor.author | 김세주 | - |
dc.contributor.author | 김찬형 | - |
dc.contributor.author | 이홍식 | - |
dc.date.accessioned | 2015-06-10T12:11:11Z | - |
dc.date.available | 2015-06-10T12:11:11Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0300-9564 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/109344 | - |
dc.description.abstract | There is evidence for an association between polymorphisms of serotonin- and dopamine-related genes and temperamental personality traits. Recent findings have shown that interactions between allelic variants of the different genes may contribute to personality traits. We examined the effects of serotonin transporter-linked promoter region (5-HTTLPR) and dopamine transporter (DAT1) gene polymorphisms for associations with the Temperament and Character Inventory (TCI) temperament subscales in 209 Koreans. We found that the variants of 5-HTTLPR interacted with the DAT1 gene polymorphism to influence the HA and RD temperament subscales of TCI. Neither of these two genes affected any subscales of TCI alone. Controlling for the effects of gender and age, we found significant interactions between 5-HTTLPR and DAT1 genes on Harm Avoidance (HA) and Reward Dependence (RD) as measured by the TCI (Hotelling’s Trace = 3.0, P = 0.02). In the presence of the DAT1 10/10 genotype, subjects of group L of 5-HTTLPR had a significantly higher HA score and significantly lower RD score than those of group S (F = 5.04, df = 1, p = 0.03 and F = 8.35, df = 1, p = 0.004, respectively). These findings suggest that the variants of 5-HTTLPR interacted with the DAT1 gene polymorphism to influence the HA and RD temperament subscales of TCI. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 877~886 | - |
dc.relation.isPartOf | JOURNAL OF NEURAL TRANSMISSION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Avoidance Learning/physiology | - |
dc.subject.MESH | Brain/metabolism* | - |
dc.subject.MESH | Brain/physiopathology | - |
dc.subject.MESH | Brain Chemistry/genetics* | - |
dc.subject.MESH | Dopamine/metabolism | - |
dc.subject.MESH | Dopamine Plasma Membrane Transport Proteins/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genetic Variation/genetics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Personality/genetics* | - |
dc.subject.MESH | Polymorphism, Genetic/genetics* | - |
dc.subject.MESH | Reward | - |
dc.subject.MESH | Serotonin/metabolism | - |
dc.subject.MESH | Serotonin Plasma Membrane Transport Proteins/genetics* | - |
dc.title | An interaction between the serotonin transporter promoter region and dopamine transporter polymorphisms contributes to harm avoidance and reward dependence traits in normal healthy subjects | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | S. J. Kim | - |
dc.contributor.googleauthor | Y. S. Kim | - |
dc.contributor.googleauthor | H. S. Lee | - |
dc.contributor.googleauthor | S. Y. Kim | - |
dc.contributor.googleauthor | C.-H. Kim | - |
dc.identifier.doi | 10.1007/s00702-006-0444-3 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00604 | - |
dc.contributor.localId | A01036 | - |
dc.contributor.localId | A03332 | - |
dc.relation.journalcode | J01619 | - |
dc.identifier.eissn | 1435-1463 | - |
dc.identifier.pmid | 16604301 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00702-006-0444-3 | - |
dc.subject.keyword | Serotonin transporter gene | - |
dc.subject.keyword | dopamine transporter gene | - |
dc.subject.keyword | interaction | - |
dc.subject.keyword | harm avoidance | - |
dc.subject.keyword | reward dependence | - |
dc.contributor.alternativeName | Kim, Se Joo | - |
dc.contributor.alternativeName | Kim, Chan Hyung | - |
dc.contributor.alternativeName | Lee, Hong Shick | - |
dc.contributor.affiliatedAuthor | Kim, Se Joo | - |
dc.contributor.affiliatedAuthor | Kim, Chan Hyung | - |
dc.contributor.affiliatedAuthor | Lee, Hong Shick | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 113 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 877 | - |
dc.citation.endPage | 886 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEURAL TRANSMISSION, Vol.113(7) : 877-886, 2006 | - |
dc.identifier.rimsid | 52295 | - |
dc.type.rims | ART | - |
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