Cited 23 times in
Influence of weight reduction by sibutramine on female sexual function
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강희철 | - |
dc.date.accessioned | 2015-06-10T11:54:21Z | - |
dc.date.available | 2015-06-10T11:54:21Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0307-0565 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/108834 | - |
dc.description.abstract | Background: It is well known that selective serotonin reuptake inhibitors (SSRIs) can cause sexual dysfunction, so it is possible that sibutramine, a serotonin and norepinephrine reuptake inhibitor, could induce sexual dysfunction. Design and subjects: The effect of sibutramine on sexual function was evaluated in 46 overweight and obese (body mass index (BMI) greater than or equal to23 kg/m2) but otherwise healthy married women (28–44 years). Participants were randomly assigned at baseline to either the sibutramine or control group. The Female Sexual Function Index (FSFI) questionnaire was used to assess sexual function at baseline and after treatment with behavioral therapy plus sibutramine 10 mg once daily or behavioral therapy alone (control) for 8 weeks. Results: Mean weight loss from baseline to week 8 was -6.03% in sibutramine group and -0.38% in the control group. There was significant improvement of FSFI total score, arousal domain score and lubrication domain score in the sibutramine group (P<0.05), and significant differences in arousal, orgasm, satisfaction domain score and total score (P<0.05) in favor of sibutramine. Decreases in body weight and BMI were correlated with the improvement of arousal (r=-0.44 and r=-0.48, respectively) and orgasm (r=-0.45 and r=-0.46, respectively) domains. Conclusion: Treatment with sibutramine plus behavioral therapy did not induce sexual dysfunction and sibutramine-induced weight reduction appeared to have a positive impact on sexual function in this small group of overweight and moderately obese women. The degree of improvement in sexual function was correlated with the degree of weight reduction. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 758~763 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF OBESITY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antidepressive Agents/adverse effects* | - |
dc.subject.MESH | Antidepressive Agents/therapeutic use | - |
dc.subject.MESH | Appetite Depressants/adverse effects* | - |
dc.subject.MESH | Appetite Depressants/therapeutic use | - |
dc.subject.MESH | Behavior Therapy | - |
dc.subject.MESH | Body Composition | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Cyclobutanes/adverse effects* | - |
dc.subject.MESH | Cyclobutanes/therapeutic use | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Obesity/complications* | - |
dc.subject.MESH | Obesity/drug therapy | - |
dc.subject.MESH | Obesity/therapy | - |
dc.subject.MESH | Sexual Dysfunction, Physiological/complications | - |
dc.subject.MESH | Sexual Dysfunction, Physiological/drug therapy | - |
dc.subject.MESH | Sexual Dysfunction, Physiological/therapy | - |
dc.subject.MESH | Sexual Dysfunctions, Psychological/complications* | - |
dc.subject.MESH | Sexual Dysfunctions, Psychological/drug therapy | - |
dc.subject.MESH | Sexual Dysfunctions, Psychological/therapy | - |
dc.subject.MESH | Statistics, Nonparametric | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Weight Loss | - |
dc.title | Influence of weight reduction by sibutramine on female sexual function | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학) | - |
dc.contributor.googleauthor | K K Kim | - |
dc.contributor.googleauthor | H C Kang | - |
dc.contributor.googleauthor | S S Kim | - |
dc.contributor.googleauthor | B B Youn | - |
dc.identifier.doi | 10.1038/sj.ijo.0803198 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00105 | - |
dc.relation.journalcode | J01140 | - |
dc.identifier.eissn | 1476-5497 | - |
dc.identifier.pmid | 16404407 | - |
dc.identifier.url | http://www.nature.com/ijo/journal/v30/n5/full/0803198a.html | - |
dc.subject.keyword | sibutramine | - |
dc.subject.keyword | female sexual function | - |
dc.subject.keyword | FSFI | - |
dc.subject.keyword | weight reduction | - |
dc.contributor.alternativeName | Kang, Hee Cheol | - |
dc.contributor.affiliatedAuthor | Kang, Hee Cheol | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 30 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 758 | - |
dc.citation.endPage | 763 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF OBESITY, Vol.30(5) : 758-763, 2006 | - |
dc.identifier.rimsid | 49906 | - |
dc.type.rims | ART | - |
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