Cited 17 times in
Interaction of SOCS3 with NonO attenuates IL-1beta-dependent MUC8 gene expression.
DC Field | Value | Language |
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dc.contributor.author | 김규보 | - |
dc.contributor.author | 송경섭 | - |
dc.contributor.author | 윤주헌 | - |
dc.date.accessioned | 2015-05-19T17:14:06Z | - |
dc.date.available | 2015-05-19T17:14:06Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/107759 | - |
dc.description.abstract | The intracellular negatively regulatory mechanism which affects IL-1beta-induced MUC8 gene expression remains unclear. We found that SOCS3 overexpression suppressed IL-1beta-induced MUC8 gene expression in NCI-H292 cells, whereas silencing of SOCS3 restored IL-1beta-induced MUC8 gene expression. Sequentially activated ERK1/2, RSK1, and CREB by IL-1beta were not affected by SOCS3, indicating that SOCS3 has an independent mechanism of action. Using immunoprecipitaion and nano LC mass analysis, we found that SOCS3 bound NonO (non-POU-domain containing, octamer-binding domain protein) in the absence of IL-1beta, whereas IL-1beta treatment dissociated the direct binding of SOCS3 and NonO. A dominant-negative SOCS3 mutant (Y204F/Y221F) did not bind to NonO. Interestingly, SOCS3 overexpression dramatically suppressed MUC8 gene expression in cells transfected with wild-type or siRNA of NonO. Moreover, silencing of SOCS3 dramatically increased NonO-mediated MUC8 gene expression caused by IL-1beta compared to NonO overexpression alone, suggesting that SOCS3 acts as a suppressor by regulating the action of NonO. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 946~951 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Gene Expression | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-1beta/genetics | - |
dc.subject.MESH | Interleukin-1beta/metabolism* | - |
dc.subject.MESH | Mucins/genetics* | - |
dc.subject.MESH | Nuclear Matrix-Associated Proteins/genetics | - |
dc.subject.MESH | Nuclear Matrix-Associated Proteins/metabolism* | - |
dc.subject.MESH | Octamer Transcription Factors/genetics | - |
dc.subject.MESH | Octamer Transcription Factors/metabolism* | - |
dc.subject.MESH | RNA-Binding Proteins/genetics | - |
dc.subject.MESH | RNA-Binding Proteins/metabolism* | - |
dc.subject.MESH | Suppressor of Cytokine Signaling 3 Protein | - |
dc.subject.MESH | Suppressor of Cytokine Signaling Proteins/antagonists & inhibitors | - |
dc.subject.MESH | Suppressor of Cytokine Signaling Proteins/genetics | - |
dc.subject.MESH | Suppressor of Cytokine Signaling Proteins/metabolism* | - |
dc.subject.MESH | Transcriptional Activation* | - |
dc.subject.MESH | Ubiquitination | - |
dc.title | Interaction of SOCS3 with NonO attenuates IL-1beta-dependent MUC8 gene expression. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학) | - |
dc.contributor.googleauthor | Kyoung Seob Song | - |
dc.contributor.googleauthor | Kyubo Kim | - |
dc.contributor.googleauthor | Kwang Chul Chung | - |
dc.contributor.googleauthor | Jae Hong Seol | - |
dc.contributor.googleauthor | Joo-Heon Yoon | - |
dc.identifier.doi | 10.1016/j.bbrc.2008.10.084 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00323 | - |
dc.contributor.localId | A02604 | - |
dc.contributor.localId | A02010 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 18952062 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X08020755 | - |
dc.subject.keyword | IL-1β | - |
dc.subject.keyword | Inflammation | - |
dc.subject.keyword | MUC8 | - |
dc.subject.keyword | SOCS3 | - |
dc.subject.keyword | NonO | - |
dc.contributor.alternativeName | Kim, Kyu Bo | - |
dc.contributor.alternativeName | Song, Kyoung Seob | - |
dc.contributor.alternativeName | Yoon, Joo Heon | - |
dc.contributor.affiliatedAuthor | Kim, Kyu Bo | - |
dc.contributor.affiliatedAuthor | Yoon, Joo Heon | - |
dc.contributor.affiliatedAuthor | Song, Kyoung Seob | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 377 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 946 | - |
dc.citation.endPage | 951 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.377(3) : 946-951, 2008 | - |
dc.identifier.rimsid | 34665 | - |
dc.type.rims | ART | - |
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