Cited 13 times in
Comparative analysis of ABCG2-expressing and label-retaining cells in mouse submandibular gland
DC Field | Value | Language |
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dc.contributor.author | 권혁제 | - |
dc.contributor.author | 김연정 | - |
dc.contributor.author | 정한성 | - |
dc.contributor.author | 조성원 | - |
dc.date.accessioned | 2015-05-19T16:46:55Z | - |
dc.date.available | 2015-05-19T16:46:55Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0302-766X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106934 | - |
dc.description.abstract | The submandibular gland (SMG) is a tissue that can be regenerated in a tissue injury model and that has adult stem cells capable of self-renewal and differentiation into functional cells. We have analyzed the localization of label-retaining cells (LRCs), which are putative progenitor cells, by using the BrdU-labeling method. 5-Bromo-2'-deoxyuridine (BrdU) injection followed by a long chasing period permitted the identification of LRCs based on the slow-cycling characteristic. In order to confirm the accurate localization of LRCs, BrdU and SMG-specific markers, including aquaporin5, cytokeratin, and smooth muscle actin, were examined by double-immunofluorescence staining. We found that LRCs were distributed in the acinus, duct, myoepithelium, and connective tissue. Moreover, ABCG2 (a known stem cell marker) was used for the characterization of LRCs and the localization of cells as putative stem/progenitor cells. ABCG2-expressing cells were distributed in various regions of the SMG but did not co-localize with LRCs. We suggest that putative progenitor cells exist in various regions of the SMG and have diverse capacities to differentiate into specific cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 47~53 | - |
dc.relation.isPartOf | CELL AND TISSUE RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | - |
dc.subject.MESH | ATP-Binding Cassette Transporters/biosynthesis* | - |
dc.subject.MESH | Actins/metabolism | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Aquaporin 5/metabolism | - |
dc.subject.MESH | Bromodeoxyuridine/chemistry | - |
dc.subject.MESH | Keratins/metabolism | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | Stem Cells/cytology* | - |
dc.subject.MESH | Stem Cells/metabolism | - |
dc.subject.MESH | Submandibular Gland/cytology* | - |
dc.subject.MESH | Submandibular Gland/metabolism | - |
dc.title | Comparative analysis of ABCG2-expressing and label-retaining cells in mouse submandibular gland | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Yeun-Jung Kim | - |
dc.contributor.googleauthor | Hyuk-Jae Kwon | - |
dc.contributor.googleauthor | Naoshi Shinozaki | - |
dc.contributor.googleauthor | Sadamitsu Hashimoto | - |
dc.contributor.googleauthor | Masaki Shimono | - |
dc.contributor.googleauthor | Sung-Won Cho | - |
dc.contributor.googleauthor | Han-Sung Jung | - |
dc.identifier.doi | 10.1007/s00441-008-0667-8 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00261 | - |
dc.contributor.localId | A03758 | - |
dc.contributor.localId | A03837 | - |
dc.contributor.localId | A00693 | - |
dc.relation.journalcode | J00474 | - |
dc.identifier.eissn | 1432-0878 | - |
dc.identifier.pmid | 18688650 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00441-008-0667-8 | - |
dc.subject.keyword | Label-retaining cells | - |
dc.subject.keyword | BrdU | - |
dc.subject.keyword | ABCG2 | - |
dc.subject.keyword | Progenitor cell | - |
dc.subject.keyword | Submandibular gland | - |
dc.subject.keyword | Mouse (ICR) | - |
dc.contributor.alternativeName | Kwon, Hyuk Jae | - |
dc.contributor.alternativeName | Kim, Yeun Jung | - |
dc.contributor.alternativeName | Jung, Han Sung | - |
dc.contributor.alternativeName | Cho, Sung Won | - |
dc.contributor.affiliatedAuthor | Kwon, Hyuk Jae | - |
dc.contributor.affiliatedAuthor | Jung, Han Sung | - |
dc.contributor.affiliatedAuthor | Cho, Sung Won | - |
dc.contributor.affiliatedAuthor | Kim, Yeun Jung | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 334 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 47 | - |
dc.citation.endPage | 53 | - |
dc.identifier.bibliographicCitation | CELL AND TISSUE RESEARCH, Vol.334(1) : 47-53, 2008 | - |
dc.identifier.rimsid | 56378 | - |
dc.type.rims | ART | - |
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