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Agmatine inhibits hypoxia-induced TNF-alpha release from cultured retinal ganglion cells
DC Field | Value | Language |
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dc.contributor.author | 성공제 | - |
dc.contributor.author | 홍사민 | - |
dc.contributor.author | 김찬윤 | - |
dc.date.accessioned | 2015-05-19T16:45:27Z | - |
dc.date.available | 2015-05-19T16:45:27Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0327-9545 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106888 | - |
dc.description.abstract | The effect of hypoxia on the release of tumor necrosis factor-alpha (TNF-alpha) in transformed rat retinal ganglion cells (RGCs) and the effect of agmatine on the hypoxia-induced production of TNF-alpha in RGCs were evaluated. RGCs were cultured under hypoxic conditions with 5% oxygen, with or without 100 microM agmatine. The expression levels of TNF-alpha and its receptor-1 (TNF-R1) were investigated by Western blot analysis. After 6 hours of hypoxia, we noted an increase in TNF-alpha production in RGCs. Agmatine significantly reduced TNF-alpha level after 12 hours of hypoxic treatment. The expression of TNF-R1 was not affected by the hypoxia or agmatine treatment. Our results show that agmatine inhibits the TNF-alpha production of RGCs in hypoxic condition. These results demonstrate a possible neuroprotective mechanism for agmatine against hypoxic damage in RGCs. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 201~205 | - |
dc.relation.isPartOf | BIOCELL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Agmatine/pharmacology* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Hypoxia* | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Retinal Ganglion Cells/cytology | - |
dc.subject.MESH | Retinal Ganglion Cells/drug effects* | - |
dc.subject.MESH | Retinal Ganglion Cells/metabolism | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/metabolism* | - |
dc.title | Agmatine inhibits hypoxia-induced TNF-alpha release from cultured retinal ganglion cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학) | - |
dc.contributor.googleauthor | Samin Hong | - |
dc.contributor.googleauthor | Kyoungsoo Park | - |
dc.contributor.googleauthor | Chan Yun Kim | - |
dc.contributor.googleauthor | Gong Je Seong | - |
dc.identifier.doi | 18825914 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01946 | - |
dc.contributor.localId | A04395 | - |
dc.contributor.localId | A01035 | - |
dc.relation.journalcode | J00280 | - |
dc.identifier.eissn | 1667-5746 | - |
dc.identifier.pmid | 18825914 | - |
dc.identifier.url | http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452008000200006 | - |
dc.subject.keyword | Agmatine/pharmacology* | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | Cell Hypoxia* | - |
dc.subject.keyword | Cells, Cultured | - |
dc.subject.keyword | Rats | - |
dc.subject.keyword | Rats, Sprague-Dawley | - |
dc.subject.keyword | Retinal Ganglion Cells/cytology | - |
dc.subject.keyword | Retinal Ganglion Cells/drug effects* | - |
dc.subject.keyword | Retinal Ganglion Cells/metabolism | - |
dc.subject.keyword | Tumor Necrosis Factor-alpha/metabolism* | - |
dc.contributor.alternativeName | Seong, Gong Je | - |
dc.contributor.alternativeName | Hong, Sa Min | - |
dc.contributor.alternativeName | Kim, Chan Yun | - |
dc.contributor.affiliatedAuthor | Seong, Gong Je | - |
dc.contributor.affiliatedAuthor | Hong, Sa Min | - |
dc.contributor.affiliatedAuthor | Kim, Chan Yun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 32 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 201 | - |
dc.citation.endPage | 205 | - |
dc.identifier.bibliographicCitation | BIOCELL, Vol.32(2) : 201-205, 2008 | - |
dc.identifier.rimsid | 50916 | - |
dc.type.rims | ART | - |
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