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Lysophosphatidylcholine Increases Ca Current via Activation of Protein Kinase C in Rabbit Portal Vein Smooth Muscle Cells.
DC Field | Value | Language |
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dc.contributor.author | 안덕선 | - |
dc.contributor.author | 이영호 | - |
dc.contributor.author | 정승수 | - |
dc.contributor.author | 김영환 | - |
dc.contributor.author | 남택상 | - |
dc.date.accessioned | 2015-05-19T16:38:48Z | - |
dc.date.available | 2015-05-19T16:38:48Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106684 | - |
dc.description.abstract | Lysophosphatidylcholine (LPC), a metabolite of membrane phospholipids by phospholipase A(2), has been considered responsible for the development of abnormal vascular reactivity during atherosclerosis. Ca(2+) influx was shown to be augmented in atherosclerotic artery which might be responsible for abnormal vascular reactivity. However, the mechanism underlying Ca(2+) influx change in atherosclerotic artery remains undetermined. The purpose of the present study was to examine the effects of LPC on L-type Ca(2+) current (I(Ca(L))) activity and to elucidate the mechanism of LPC-induced change of I(Ca(L)) in rabbit portal vein smooth muscle cells using whole cell patch clamp. Extracellular application of LPC increased I(Ca(L)) through whole test potentials, and this effect was readily reversed by washout. Steady state voltage dependency of activation or inactivation properties of I(Ca(L)) was not significantly changed by LPC. Staurosporine (100 nM) or chelerythrine (3 microM), which is a potent inhibitor of PKC, significantly decreased basal I(Ca(L)), and LPC-induced increase of I(Ca(L)) was significantly suppressed in the presence of PKC inhibitors. On the other hand, application of PMA, an activator of PKC, increased basal I(Ca(L)) significantly, and LPC-induced enhancement of I(Ca(L)) was abolished by pretreatment of the cells with PMA. These findings suggest that LPC increased I(Ca(L)) in vascular smooth muscle cells by a pathway that involves PKC, and that LPC-induced increase of I(Ca(L)) might be, at least in part, responsible for increased Ca(2+) influx in atherosclerotic artery | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 31~35 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Lysophosphatidylcholine Increases Ca Current via Activation of Protein Kinase C in Rabbit Portal Vein Smooth Muscle Cells. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | Seungsoo Jung | - |
dc.contributor.googleauthor | Youngho Lee | - |
dc.contributor.googleauthor | Sungsik Han | - |
dc.contributor.googleauthor | Youngwhan Kim | - |
dc.contributor.googleauthor | Taiksang Nam | - |
dc.contributor.googleauthor | Ducksun Ahn | - |
dc.identifier.doi | 10.4196/kjpp.2008.12.1.31 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02223 | - |
dc.contributor.localId | A02968 | - |
dc.contributor.localId | A03643 | - |
dc.contributor.localId | A00732 | - |
dc.contributor.localId | A01271 | - |
dc.relation.journalcode | J02104 | - |
dc.identifier.eissn | 2093-3827 | - |
dc.identifier.pmid | 20157391 | - |
dc.subject.keyword | Ca2+ current | - |
dc.subject.keyword | Lysophosphatidylcholine | - |
dc.subject.keyword | Protein kinase C | - |
dc.subject.keyword | Vascular smooth muscle | - |
dc.contributor.alternativeName | Ahn, Duk Sun | - |
dc.contributor.alternativeName | Lee, Young Ho | - |
dc.contributor.alternativeName | Chung, Seung Soo | - |
dc.contributor.alternativeName | Kim, Young Hwan | - |
dc.contributor.alternativeName | Nam, Taick Sang | - |
dc.contributor.affiliatedAuthor | Ahn, Duk Sun | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Chung, Seung Soo | - |
dc.contributor.affiliatedAuthor | Kim, Young Hwan | - |
dc.contributor.affiliatedAuthor | Nam, Taick Sang | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 31 | - |
dc.citation.endPage | 35 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, Vol.12(1) : 31-35, 2008 | - |
dc.identifier.rimsid | 46657 | - |
dc.type.rims | ART | - |
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