Cited 35 times in
Plasma carotenoids, retinol and tocopherol levels and the risk of ovarian cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김재훈 | - |
dc.date.accessioned | 2015-04-24T17:45:46Z | - |
dc.date.available | 2015-04-24T17:45:46Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0001-6349 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/106021 | - |
dc.description.abstract | OBJECTIVE: We investigated the relation between plasma carotenoids, retinol and tocopherol levels and ovarian cancer risk in Korean women. DESIGN: Hospital-based case-control study. SETTING: Six tertiary medical institutes in Korea. POPULATION: Forty-five epithelial ovarian cancers and 135 age-matched controls. METHODS: Preoperative plasma concentrations of beta-carotene, lycopene, zeaxanthin plus lutein, retinol, alpha-tocopherol, and gamma-tocopherol were measured by reverse-phase, gradient high-pressure liquid chromatography. MAIN OUTCOME MEASURES: Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated by tertiles to evaluate the effect of micronutrients on endometrial cancer risk after adjustment for body mass (BMI) index, menopause, parity, oral contraceptive use, smoking status, and alcohol consumption status. RESULTS: Women in the highest tertile for beta-carotene had 0.12-times the risk of ovarian cancer of in the lowest tertile (OR 0.12; 95%CI 0.04-0.36). Women with the highest tertiles of lycopene (OR 0.09; 95%CI 0.03-0.32), zeaxanthin/lutein (OR 0.21; 95%CI 0.09-0.52), retinol (OR 0.45; 95%CI 0.21-0.98), alpha-tocopherol (OR 0.23; 95%CI 0.10-0.53) and gamma-tocopherol (OR 0.28; 95%CI 0.11-0.70) had lower risk of ovarian cancer than women in the lowest tertiles. Results were consistent across strata of socio-epidemiologic factors. CONCLUSIONS: Micronutrients, specifically ss-carotene, lycopene, zeaxanthin, lutein, retinol, alpha-tocopherol, and gamma-tocopherol, may play a role in reducing the risk of ovarian cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Antioxidants/metabolism | - |
dc.subject.MESH | Carotenoids/blood* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Chromatography, High Pressure Liquid | - |
dc.subject.MESH | Confidence Intervals | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea/epidemiology | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasms, Glandular and Epithelial/blood* | - |
dc.subject.MESH | Neoplasms, Glandular and Epithelial/epidemiology | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Ovarian Neoplasms/blood* | - |
dc.subject.MESH | Ovarian Neoplasms/epidemiology | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Tocopherols/blood* | - |
dc.subject.MESH | Vitamin A/blood* | - |
dc.title | Plasma carotenoids, retinol and tocopherol levels and the risk of ovarian cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | NAN-HEE JEONG | - |
dc.contributor.googleauthor | EUN-SEOP SONG | - |
dc.contributor.googleauthor | JONG-MIN LEE | - |
dc.contributor.googleauthor | KWANG-BEOM LEE | - |
dc.contributor.googleauthor | MI-KYUNG KIM | - |
dc.contributor.googleauthor | JI-EUN CHEON | - |
dc.contributor.googleauthor | JAE-KWAN LEE | - |
dc.contributor.googleauthor | SUNG-KYONG SON | - |
dc.contributor.googleauthor | JUNG-PIL LEE | - |
dc.contributor.googleauthor | JAE-HOON KIM | - |
dc.contributor.googleauthor | SOO-YOUNG HUR | - |
dc.contributor.googleauthor | YONG-IL KWON | - |
dc.identifier.doi | 10.1080/00016340902807215 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00876 | - |
dc.relation.journalcode | J00022 | - |
dc.identifier.eissn | 1600-0412 | - |
dc.identifier.pmid | 19266359 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1080/00016340902807215/abstract | - |
dc.subject.keyword | Carotenoids | - |
dc.subject.keyword | vitamin A | - |
dc.subject.keyword | tocopherol | - |
dc.subject.keyword | ovarian cancer | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hoon | - |
dc.citation.volume | 88 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 457 | - |
dc.citation.endPage | 462 | - |
dc.identifier.bibliographicCitation | ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, Vol.88(4) : 457-462, 2009 | - |
dc.identifier.rimsid | 56977 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.