Cited 19 times in
Prostate cancer cell-specific VEGF siRNA delivery system using cell targeting peptide conjugated polyplexes
DC Field | Value | Language |
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dc.contributor.author | 김선화 | - |
dc.date.accessioned | 2015-04-24T17:40:13Z | - |
dc.date.available | 2015-04-24T17:40:13Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1061-186X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105842 | - |
dc.description.abstract | A polymeric gene carrier was developed to deliver vascular endothelial growth factor (VEGF) small interfering RNA (siRNA) for prostate cancer cells in a target-specific manner. Prostate cancer-binding peptide (PCP) was conjugated with polyethylenimine (PEI) via a poly(ethylene glycol) (PEG) linker (PEI-PEG-PCP). The PEI-PEG-PCP conjugate could effectively condense siRNA to form stable polyelectrolyte complexes (polyplexes) with an average diameter of approximately 150 nm in an aqueous solution. VEGF siRNA/PEI-PEG-PCP polyplexes exhibited significantly higher VEGF inhibition efficiency than PCP-unmodified polycationic carriers (PEI-PEG or PEI) in human prostate carcinoma cells (PC-3 cells). The enhanced gene silencing activity of VEGF siRNA/PEI-PEG-PCP was maintained even under serum conditions, owing to the steric stabilization of the polyplexes with hydrophilic PEG grafts. Confocal microscopic studies revealed that the siRNA/PEI-PEG-PCP polyplexes were delivered into PC-3 cells in a PCP ligand-specific manner | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 311~317 | - |
dc.relation.isPartOf | JOURNAL OF DRUG TARGETING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Gene Silencing* | - |
dc.subject.MESH | Gene Targeting | - |
dc.subject.MESH | Gene Transfer Techniques | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ligands | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microscopy, Confocal | - |
dc.subject.MESH | Polyethylene Glycols/chemistry | - |
dc.subject.MESH | Polyethyleneimine/chemistry | - |
dc.subject.MESH | Prostatic Neoplasms/genetics | - |
dc.subject.MESH | Prostatic Neoplasms/therapy* | - |
dc.subject.MESH | RNA, Small Interfering/administration & dosage* | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/genetics* | - |
dc.title | Prostate cancer cell-specific VEGF siRNA delivery system using cell targeting peptide conjugated polyplexes | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) | - |
dc.contributor.googleauthor | Sun Hwa Kim | - |
dc.contributor.googleauthor | Soo Hyeon Lee | - |
dc.contributor.googleauthor | Huayu Tian | - |
dc.contributor.googleauthor | Xuesi Chen | - |
dc.contributor.googleauthor | Tae Gwan Park | - |
dc.identifier.doi | 10.1080/10611860902767232 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00561 | - |
dc.relation.journalcode | J01381 | - |
dc.identifier.eissn | 1029-2330 | - |
dc.identifier.pmid | 19242850 | - |
dc.identifier.url | http://informahealthcare.com/doi/abs/10.1080/10611860902767232 | - |
dc.subject.keyword | Prostate cancer–targeted siRNA delivery system | - |
dc.subject.keyword | VEGF | - |
dc.subject.keyword | siRNA | - |
dc.subject.keyword | prostate cancer–binding peptide (PCP) | - |
dc.contributor.alternativeName | Kim, Sun Hwa | - |
dc.contributor.affiliatedAuthor | Kim, Sun Hwa | - |
dc.citation.volume | 17 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 311 | - |
dc.citation.endPage | 317 | - |
dc.identifier.bibliographicCitation | JOURNAL OF DRUG TARGETING, Vol.17(4) : 311-317, 2009 | - |
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