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Menthol regulates TRPM8-independent processes in PC-3 prostate cancer cells

Authors
 Su-Hwa Kim  ;  Joo-Hyun Nam  ;  Eun-Jung Park  ;  Byung-Joo Kim  ;  Sung-Joon Kim  ;  Insuk So  ;  Ju-Hong Jeon 
Citation
 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, Vol.1792(1) : 33-38, 2009 
Journal Title
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
ISSN
 0925-4439 
Issue Date
2009
MeSH
Calcium/metabolism ; Calcium Channels/metabolism ; Cell Death/drug effects ; Cell Death/physiology ; Cell Line, Tumor ; Humans ; Ion Transport/drug effects ; JNK Mitogen-Activated Protein Kinases/metabolism ; Male ; Menthol/pharmacology* ; Nerve Tissue Proteins/metabolism ; Prostatic Neoplasms/drug therapy* ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism* ; Prostatic Neoplasms/pathology ; Signal Transduction/drug effects ; TRPA1 Cation Channel ; TRPM Cation Channels/genetics ; TRPM Cation Channels/metabolism* ; Transient Receptor Potential Channels/metabolism
Keywords
Menthol ; TRPM8 ; Ca2+ ; Prostate cancer ; Cell death
Abstract
Menthol, a naturally occurring compound from peppermint oil, binds and activates the TRPM8 Ca(2+)-permeable channel that exhibits abnormal expression patterns in prostate cancer, suggesting that TRPM8 links Ca(2+) transport pathways to tumor biology. We thus investigated the cellular responses of prostate cancer cells to menthol. Here we found that menthol increases [Ca(2+)](i) via Ca(2+) influx mechanism(s) independent of TRPM8 in PC-3 cells. We demonstrated that menthol induces cell death at supramillimolar concentrations in PC-3 cells and the cell death is not suppressed by low extracellular Ca(2+) condition which indicates that menthol-induced cell death is not associated with Ca(2+) influx pathways. In addition, we showed that menthol increases a phosphorylated form of c-jun N-terminal kinase (JNK) in PC-3 cells through TRPM8-independent mechanisms. Thus, our data indicate that there is an apparent lack of causality between TRPM8 activation and menthol-induced cell death and that menthol can regulate TRPM8-independent Ca(2+)-transport and cellular processes
Full Text
http://www.sciencedirect.com/science/article/pii/S0925443908001877
DOI
10.1016/j.bbadis.2008.09.012
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
Yonsei Authors
Nam, Joo Hyun(남주현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/105802
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