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Clinicopathologic Characteristics of Left-Sided Colon Cancers with High Microsatellite Instability
DC Field | Value | Language |
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dc.contributor.author | 김현기 | - |
dc.contributor.author | 김호근 | - |
dc.contributor.author | 박영년 | - |
dc.contributor.author | 송시영 | - |
dc.date.accessioned | 2015-04-24T17:38:11Z | - |
dc.date.available | 2015-04-24T17:38:11Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1738-1843 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105777 | - |
dc.description.abstract | BACKGROUND: High microsatellite instability (MSI-H) colorectal carcinomas (CRCs) with numerous mutations in the microsatellite sequence are characterized by a right-sided preponderance, frequent peritumoral and intratumoral lymphocytic infiltration, and frequent mucin production. However, no study has correlated anatomic site and type of genetic changes with clinicopathologic changes. METHODS: We analyzed the histopathologic features of 135 MSI-H CRCs and compared them to 140 microsatellite stable (MSS) CRCs. Histopathologic changes in MSI-H were further analyzed according to anatomic sites and genetic changes. RESULTS: MSI-H CRCs showed previously reported clinicopathologic findings; a right-sided preponderance, an increased number of mucinous carcinomas, and peritumoral lymphoid reactions (p<0.001 for each variable). Increased serum CEA levels showed an MSS CRC preponderance (p=0.013). We further analyzed the histologic differences between right- and left-sided MSI-H tumors. We found that MSI-H CRCs on both sides had similar clinicopathologic findings, except for higher tumor stage (p=0.048) and less frequent abnormal CEA levels in left-sided MSI-H tumors (p=0.027). We found that not all clinicopathologic features were different between hereditary nonpolyposis colorectal cancers (HNPCCs) and sporadic MSI-H CRCs. CONCLUSIONS: These findings indicate that MSI-H CRCs of the left colon have similar clinicopathologic characteristics as right-sided MSI-H CRCs. We did not find any significant clinicopathological difference between HNPCCs and sporadic MSI-H CRCs | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 428~434 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Clinicopathologic Characteristics of Left-Sided Colon Cancers with High Microsatellite Instability | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Sang Kyum Kim | - |
dc.contributor.googleauthor | Junjeong Choi | - |
dc.contributor.googleauthor | Hyun Ki Kim | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.contributor.googleauthor | Si Young Song | - |
dc.contributor.googleauthor | Hoguen Kim | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01108 | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A02035 | - |
dc.relation.journalcode | J02092 | - |
dc.identifier.eissn | 2092-8920 | - |
dc.subject.keyword | Colorectal neoplasm | - |
dc.subject.keyword | Microsatellite instability | - |
dc.subject.keyword | Colorectal neoplasms, hereditary nonpolyposis | - |
dc.contributor.alternativeName | Kim, Hyun Ki | - |
dc.contributor.alternativeName | Kim, Ho Keun | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.alternativeName | Song, Si Young | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Ki | - |
dc.contributor.affiliatedAuthor | Kim, Ho Keun | - |
dc.contributor.affiliatedAuthor | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | Song, Si Young | - |
dc.citation.volume | 43 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 428 | - |
dc.citation.endPage | 434 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PATHOLOGY , Vol.43(5) : 428-434, 2009 | - |
dc.identifier.rimsid | 43286 | - |
dc.type.rims | ART | - |
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