Cited 18 times in
Variability of response time as a predictor of methylphenidate treatment response in korean children with attention deficit hyperactivity disorder
DC Field | Value | Language |
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dc.contributor.author | 송동호 | - |
dc.contributor.author | 신의진 | - |
dc.date.accessioned | 2015-04-24T17:25:54Z | - |
dc.date.available | 2015-04-24T17:25:54Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/105387 | - |
dc.description.abstract | PURPOSE: Methylphenidate (MPH) is an effective medication for the treatment of attention deficit hyperactivity disorder (ADHD). However, about 30% of patients do not respond to or are unable to tolerate MPH. Based on previous findings, we hypothesized that great variability in response time (RT) among Korean children with ADHD on a computerized continuous performance attention test would be related to poor MPH treatment response. MATERIALS AND METHODS: Children (ages 6-18 years) with ADHD were recruited for a prospective 12-week, open-labeled, multicenter study to examine optimal dosage of OROS methylphenidate. Of the 144 subjects selected, 28 dropped out due to adverse events, medication noncompliance, or follow-up loss, and an additional 26 subjects with comorbid disorders were excluded from statistical analyses. We defined 'responders' as subjects who received a score of less than 18 on the attention deficit hyperactivity disorder rating scale (ARS; Korean version, K-ARS) and a score of 1 or 2 on the Clinical Global Impression-Improvement scale (CGI-I). RT variability was assessed with the ADHD diagnostic system (ADS). RESULTS: Fifty-nine (67%) subjects responded to MPH treatment. The non-responders showed greater RT variability at baseline (Mann Whitney U = 577.0, p < 0.01). Baseline RT variability was a significant predictor of MPH response (Nagelkerke R(2) = 0.136, p < 0.01). It predicted 94.9% of responder, 17.2% of non-responder and 69.3% of overall group. CONCLUSION: High RT variability may predict poor response to MPH treatment in children with ADHD | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 650~655 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Attention Deficit Disorder with Hyperactivity/drug therapy* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Methylphenidate/therapeutic use* | - |
dc.subject.MESH | Reaction Time* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Variability of response time as a predictor of methylphenidate treatment response in korean children with attention deficit hyperactivity disorder | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | Seung-Hye Lee | - |
dc.contributor.googleauthor | Dong-Ho Song | - |
dc.contributor.googleauthor | Bung-Nyun Kim | - |
dc.contributor.googleauthor | Yoo Sook Joung | - |
dc.contributor.googleauthor | Eun Hye Ha | - |
dc.contributor.googleauthor | Keun-Ah Cheon | - |
dc.contributor.googleauthor | Yee-Jin Shin | - |
dc.contributor.googleauthor | Hee Jeong Yoo | - |
dc.contributor.googleauthor | Dong-Won Shin | - |
dc.identifier.doi | 10.3349/ymj.2009.50.5.650 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02018 | - |
dc.contributor.localId | A02136 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 19881968 | - |
dc.subject.keyword | ADHD | - |
dc.subject.keyword | methylphenidate | - |
dc.subject.keyword | response time variability | - |
dc.contributor.alternativeName | Song, Dong Ho | - |
dc.contributor.alternativeName | Shin, Yee Jin | - |
dc.contributor.affiliatedAuthor | Song, Dong Ho | - |
dc.contributor.affiliatedAuthor | Shin, Yee Jin | - |
dc.citation.volume | 50 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 650 | - |
dc.citation.endPage | 655 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.50(5) : 650-655, 2009 | - |
dc.identifier.rimsid | 51653 | - |
dc.type.rims | ART | - |
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