Cited 83 times in
Clinical features and treatment outcomes of advanced stage primary hepatic angiosarcoma
DC Field | Value | Language |
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dc.contributor.author | 김혜련 | - |
dc.contributor.author | 노재경 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 박영년 | - |
dc.contributor.author | 유내춘 | - |
dc.contributor.author | 전성하 | - |
dc.date.accessioned | 2015-04-24T17:09:25Z | - |
dc.date.available | 2015-04-24T17:09:25Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0923-7534 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104865 | - |
dc.description.abstract | BACKGROUND: Primary hepatic angiosarcoma is a very rare malignancy with a poor prognosis. While surgical resection has been validated as curative choice, most cases are diagnosed too late for resection. Nonetheless, treatment protocols have not been established and also there are very few reports on the clinical features and treatment outcomes. PATIENTS AND METHODS: Among 11,939 patients diagnosed with primary hepatic tumors from January 1985 to December 2007 at two centers, five patients were diagnosed with primary hepatic angiosarcoma. We analyzed patients' demographics, tumor characteristics, treatment modality, and outcomes using imaging, serology, and pathology. RESULTS: All five patients were diagnosed at advanced stage with distant metastases. The most common symptom was abdominal pain. The levels of the tumor markers were within the normal range and serological tests were negative for hepatitis B and C viruses. Two of four patients who received chemotherapy died <3 months after diagnosis, but the other two patients survived >6 months. CONCLUSIONS: A combination of chemotherapy resulted in an improved outcome for two of four patients, suggesting the potential usefulness of palliative chemotherapy to improve survival. This case study may aid in planning chemotherapy for patients with advanced hepatic angiosarcoma. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 780~787 | - |
dc.relation.isPartOf | ANNALS OF ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antineoplastic Agents/therapeutic use | - |
dc.subject.MESH | Hemangiosarcoma/drug therapy* | - |
dc.subject.MESH | Hemangiosarcoma/pathology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Liver Neoplasms/drug therapy* | - |
dc.subject.MESH | Liver Neoplasms/pathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Clinical features and treatment outcomes of advanced stage primary hepatic angiosarcoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | H. R. Kim | - |
dc.contributor.googleauthor | S. Y. Rha | - |
dc.contributor.googleauthor | S. H. Cheon | - |
dc.contributor.googleauthor | J. K. Roh | - |
dc.contributor.googleauthor | Y. N. Park | - |
dc.contributor.googleauthor | N. C. Yoo | - |
dc.identifier.doi | 10.1093/annonc/mdn702 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01166 | - |
dc.contributor.localId | A01290 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A02457 | - |
dc.contributor.localId | A03520 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J00171 | - |
dc.identifier.eissn | 1569-8041 | - |
dc.identifier.pmid | 19179547 | - |
dc.subject.keyword | chemotherapy | - |
dc.subject.keyword | primary hepatic angiosarcoma | - |
dc.subject.keyword | treatment outcomes | - |
dc.contributor.alternativeName | Kim, Hye Ryun | - |
dc.contributor.alternativeName | Roh, Jae Kyung | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.alternativeName | Yoo, Nae Choon | - |
dc.contributor.alternativeName | Cheon, Seong Ha | - |
dc.contributor.affiliatedAuthor | Kim, Hye Ryun | - |
dc.contributor.affiliatedAuthor | Roh, Jae Kyung | - |
dc.contributor.affiliatedAuthor | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | Yoo, Nae Choon | - |
dc.contributor.affiliatedAuthor | Cheon, Seong Ha | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.citation.volume | 20 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 780 | - |
dc.citation.endPage | 787 | - |
dc.identifier.bibliographicCitation | ANNALS OF ONCOLOGY, Vol.20(4) : 780-787, 2009 | - |
dc.identifier.rimsid | 42531 | - |
dc.type.rims | ART | - |
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