Cited 54 times in
Decursin and decursinol inhibit VEGF-induced angiogenesis by blocking the activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김미정 | - |
dc.contributor.author | 박광균 | - |
dc.contributor.author | 손승화 | - |
dc.contributor.author | 손주아 | - |
dc.contributor.author | 정원윤 | - |
dc.date.accessioned | 2015-04-24T16:59:53Z | - |
dc.date.available | 2015-04-24T16:59:53Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104567 | - |
dc.description.abstract | The root of Angelica gigas Nakai contains two major coumarins, which have been previously identified as decursin and decursinol. Decursin has been demonstrated to exhibit potent anti-cancer activity both in vitro and in vivo. In this study, we found that decursin and decursinol at non-cytotoxic doses inhibited the VEGF-induced proliferation, migration, and capillary-tube formation of HUVECs. Moreover, decursin and decursinol suppressed microvessel formation on chorioallantoic membranes in fertilized eggs and into mouse Matrigel plugs. The oral administration of decursin and decursinol also reduced VEGF-induced angiogenesis in Matrigel. Furthermore, decursin and decursinol reduced the phosphorylation of ERK and JNK, but not p38 MAPK, in VEGF-stimulated HUVECs. Taken together, our results reveal that decursin and decursinol inhibit VEGF-induced angiogenesis by reducing the activation of ERK and JNK in HUVECs, and possess potent in vivo anti-angiogenic activity, coupled with the advantage of oral dosing. Thus, these compounds may have the potential for the treatment of cancers dependent on VEGF-induced vascularization. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 86~92 | - |
dc.relation.isPartOf | CANCER LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Benzopyrans/pharmacology* | - |
dc.subject.MESH | Butyrates/pharmacology* | - |
dc.subject.MESH | Cell Movement | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Endothelium, Vascular/metabolism | - |
dc.subject.MESH | Extracellular Signal-Regulated MAP Kinases/metabolism* | - |
dc.subject.MESH | JNK Mitogen-Activated Protein Kinases/metabolism* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Neovascularization, Pathologic* | - |
dc.subject.MESH | Plant Extracts/metabolism | - |
dc.subject.MESH | Plant Roots/metabolism | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/metabolism* | - |
dc.title | Decursin and decursinol inhibit VEGF-induced angiogenesis by blocking the activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase. | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Seung Hwa Son | - |
dc.contributor.googleauthor | Mi-Jeong Kim | - |
dc.contributor.googleauthor | Won-Yoon Chung | - |
dc.contributor.googleauthor | Ju-Ah Son | - |
dc.contributor.googleauthor | Yeong Shik Kim | - |
dc.contributor.googleauthor | Young-Choong Kim | - |
dc.contributor.googleauthor | Sam Sik Kang | - |
dc.contributor.googleauthor | Sang-Kook Lee | - |
dc.contributor.googleauthor | Kwang-Kyun Park | - |
dc.identifier.doi | 10.1016/j.canlet.2009.02.012 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01429 | - |
dc.contributor.localId | A01979 | - |
dc.contributor.localId | A01994 | - |
dc.contributor.localId | A03676 | - |
dc.contributor.localId | A00449 | - |
dc.relation.journalcode | J00448 | - |
dc.identifier.eissn | 1872-7980 | - |
dc.identifier.pmid | 19307054 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0304383509001116 | - |
dc.subject.keyword | Decursin | - |
dc.subject.keyword | Decursinol | - |
dc.subject.keyword | Angelica gigas | - |
dc.subject.keyword | Anti-angiogenic activity | - |
dc.contributor.alternativeName | Kim, Mi Jeong | - |
dc.contributor.alternativeName | Park, Kwang Kyun | - |
dc.contributor.alternativeName | Son, Seung Hwa | - |
dc.contributor.alternativeName | Son, Ju Ah | - |
dc.contributor.alternativeName | Chung, Won Yoon | - |
dc.contributor.affiliatedAuthor | Park, Kwang Kyun | - |
dc.contributor.affiliatedAuthor | Son, Seung Hwa | - |
dc.contributor.affiliatedAuthor | Son, Ju Ah | - |
dc.contributor.affiliatedAuthor | Chung, Won Yoon | - |
dc.contributor.affiliatedAuthor | Kim, Mi Jeong | - |
dc.citation.volume | 280 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 86 | - |
dc.citation.endPage | 92 | - |
dc.identifier.bibliographicCitation | CANCER LETTERS, Vol.280(1) : 86-92, 2009 | - |
dc.identifier.rimsid | 51117 | - |
dc.type.rims | ART | - |
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