Cited 38 times in
Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea
DC Field | Value | Language |
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dc.contributor.author | 김유선 | - |
dc.contributor.author | 김철훈 | - |
dc.contributor.author | 남정모 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 이현철 | - |
dc.contributor.author | 차봉수 | - |
dc.contributor.author | 한승진 | - |
dc.contributor.author | 허규연 | - |
dc.contributor.author | 강은석 | - |
dc.contributor.author | 김명수 | - |
dc.contributor.author | 김순일 | - |
dc.date.accessioned | 2015-04-24T16:52:14Z | - |
dc.date.available | 2015-04-24T16:52:14Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0041-1337 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104329 | - |
dc.description.abstract | BACKGROUND: Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Recent genome-wide association studies have identified several genes associated with type 2 diabetes. Here, we examined the association between PTDM and 17 single nucleotide polymorphisms (SNPs) located within 15 genes in a cohort of renal allograft recipients in Korea. MATERIALS AND METHODS: A total of 589 patients who received kidney transplants between 1989 and 2007, without a history of diabetes and had a pretransplant fasting glucose less than 5.5 mmol/L were included in this study. We analyzed the association between the PTDM development and the following SNPs: TCF7L2 rs7903146, SLC30A8 rs13266634, HHEX (rs1111875, rs7923837, and rs5015480), CDKAL1 rs10946398, CDKN2A/B rs10811661, IGF2BP2 rs4402960, FTO rs8050136, WFS1 rs734312, JAZF1 rs864745, CDC123/CAMK1D rs12779790, TSPAN8 rs7961581, THADA rs7578597, ADAMTS9 rs4607103, NOTCH2 rs1092391, and KCNQ1 rs2237892. RESULTS: Eight SNPs in six genes were significantly associated with the PTDM development: TCF7L2 rs7903146 (odds ratio [OR]=2.20, P =0.016), SLC30A8 rs13266634 (OR=1.52, P =0.003), HHEX rs1111875 (OR=1.47, P =0.007), HHEX rs7923837 (OR=2.32, P =0.014), HHEX rs5015480 (OR=1.59, P =0.003), CDKAL1 rs10946398 (OR=1.43, P =0.008), CDKN2A/B rs10811661 (OR=1.33, P =0.039), and KCNQ1 rs2237892 (OR=1.46, P =0.009). CONCLUSIONS: These data suggest that genetic variations in TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, and KCNQ1 are associated with PTDM in Korea. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 693~698 | - |
dc.relation.isPartOf | TRANSPLANTATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Diabetes Complications/genetics* | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/etiology | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genetic Predisposition to Disease* | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Glucose/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney Transplantation/methods* | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Polymorphism, Single Nucleotide | - |
dc.subject.MESH | Renal Insufficiency/complications* | - |
dc.subject.MESH | Renal Insufficiency/therapy | - |
dc.title | Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.contributor.googleauthor | Myoung Soo Kim | - |
dc.contributor.googleauthor | Chul Hoon Kim | - |
dc.contributor.googleauthor | Chung Mo Nam | - |
dc.contributor.googleauthor | Seung Jin Han | - |
dc.contributor.googleauthor | Kyu Yeon Hur | - |
dc.contributor.googleauthor | Chul Woo Ahn | - |
dc.contributor.googleauthor | Bong Soo Cha | - |
dc.contributor.googleauthor | Soon Il Kim | - |
dc.contributor.googleauthor | Hyun Chul Lee | - |
dc.contributor.googleauthor | Yu Seun Kim | - |
dc.identifier.doi | 10.1097/TP.0b013e3181b29c41 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00785 | - |
dc.contributor.localId | A01057 | - |
dc.contributor.localId | A01264 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A03301 | - |
dc.contributor.localId | A03996 | - |
dc.contributor.localId | A04302 | - |
dc.contributor.localId | A04343 | - |
dc.contributor.localId | A00068 | - |
dc.contributor.localId | A00649 | - |
dc.contributor.localId | A00424 | - |
dc.relation.journalcode | J02754 | - |
dc.identifier.eissn | 1534-6080 | - |
dc.identifier.pmid | 19741467 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00007890-200909150-00014&LSLINK=80&D=ovft | - |
dc.subject.keyword | Posttransplantation diabetes mellitus | - |
dc.subject.keyword | Genetic variation | - |
dc.subject.keyword | Kidney transplantation | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.alternativeName | Kim, Chul Hoon | - |
dc.contributor.alternativeName | Nam, Jung Mo | - |
dc.contributor.alternativeName | Ahn, Chul Woo | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.alternativeName | Han, Seung Jin | - |
dc.contributor.alternativeName | Hur, Kyu Yeon | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Kim, Myoung Soo | - |
dc.contributor.alternativeName | Kim, Soon Il | - |
dc.contributor.affiliatedAuthor | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | Kim, Chul Hoon | - |
dc.contributor.affiliatedAuthor | Nam, Jung Mo | - |
dc.contributor.affiliatedAuthor | Ahn, Chul Woo | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Han, Seung Jin | - |
dc.contributor.affiliatedAuthor | Hur, Kyu Yeon | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Kim, Soon Il | - |
dc.contributor.affiliatedAuthor | Kim, Myoung Soo | - |
dc.citation.volume | 88 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 693 | - |
dc.citation.endPage | 698 | - |
dc.identifier.bibliographicCitation | TRANSPLANTATION, Vol.88(5) : 693-698, 2009 | - |
dc.identifier.rimsid | 52597 | - |
dc.type.rims | ART | - |
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