Cited 42 times in
Low-dose craniospinal irradiation as a definitive treatment for intracranial germinoma
DC Field | Value | Language |
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dc.contributor.author | 김동석 | - |
dc.contributor.author | 서창옥 | - |
dc.contributor.author | 조재호 | - |
dc.contributor.author | 최중언 | - |
dc.date.accessioned | 2015-04-24T16:33:50Z | - |
dc.date.available | 2015-04-24T16:33:50Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0167-8140 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103749 | - |
dc.description.abstract | PURPOSE: To determine the optimal radiotherapy (RT) dose and volume for treatment of intracranial germinoma. MATERIALS AND METHODS: Eighty-one intracranial germinoma patients (33 pathologically-verified; 48 presumed by radiosensitivity testing) treated with RT alone between 1971 and 2002 were analyzed. The RT volume varied from focal (13) to whole brain (8), or to the entire neuraxis (60). All the cases after 1982 received craniospinal irradiation (CSI). Radiation dose was reduced gradually during the study period from 59 to 39.3 Gy for primary tumors, and from 34.2 to 19.5 Gy for the neuraxis. The median follow-up time was 120 months (48-260 months). RESULTS: Five- and ten-year relapse-free survival rates were 98.8% and 94.1%, respectively. All the recurrences occurred in the patients who received local (4/13) or whole brain RT (1/8). None of the patients who received CSI suffered from a recurrence. Forty-six patients received 45 Gy or less to the primary site and 22 patients received less than 20 Gy to the spinal axis. CONCLUSION: Low-dose CSI-based RT should remain the standard treatment for intracranial germinoma. The RT dose can be reduced to 39.3 Gy for primary tumor sites and to 19.5 Gy for the spinal axis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 75~79 | - |
dc.relation.isPartOf | RADIOTHERAPY AND ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Brain Neoplasms/pathology | - |
dc.subject.MESH | Brain Neoplasms/radiotherapy* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Cranial Irradiation/methods* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Germinoma/pathology | - |
dc.subject.MESH | Germinoma/radiotherapy* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neoplasm Recurrence, Local | - |
dc.subject.MESH | Quality of Life | - |
dc.subject.MESH | Radiotherapy Dosage | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Low-dose craniospinal irradiation as a definitive treatment for intracranial germinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | Jaeho Cho | - |
dc.contributor.googleauthor | Joong-Uhn Choi | - |
dc.contributor.googleauthor | Dong-Seok Kim | - |
dc.contributor.googleauthor | Chang-Ok Suh | - |
dc.identifier.doi | 10.1016/j.radonc.2008.10.012 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00402 | - |
dc.contributor.localId | A01919 | - |
dc.contributor.localId | A04194 | - |
dc.contributor.localId | A03901 | - |
dc.relation.journalcode | J02597 | - |
dc.identifier.eissn | 1879-0887 | - |
dc.identifier.pmid | 19019472 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0167814008005653 | - |
dc.subject.keyword | Intracranial germinoma | - |
dc.subject.keyword | Optimal radiotherapy | - |
dc.subject.keyword | Craniospinal irradiation | - |
dc.contributor.alternativeName | Kim, Dong Seok | - |
dc.contributor.alternativeName | Suh, Chang Ok | - |
dc.contributor.alternativeName | Cho, Jae Ho | - |
dc.contributor.alternativeName | Choi, Joong Uhn | - |
dc.contributor.affiliatedAuthor | Kim, Dong Seok | - |
dc.contributor.affiliatedAuthor | Suh, Chang Ok | - |
dc.contributor.affiliatedAuthor | Choi, Joong Uhn | - |
dc.contributor.affiliatedAuthor | Cho, Jae Ho | - |
dc.citation.volume | 91 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 75 | - |
dc.citation.endPage | 79 | - |
dc.identifier.bibliographicCitation | RADIOTHERAPY AND ONCOLOGY, Vol.91(1) : 75-79, 2009 | - |
dc.identifier.rimsid | 36666 | - |
dc.type.rims | ART | - |
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