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원격전이없이 술 전 Prostate-Specific Antigen (PSA) 20 ng/ml 이상인 전립선암 환자에서의 근치적 전립선적출술의 결과
DC Field | Value | Language |
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dc.contributor.author | 최영득 | - |
dc.contributor.author | 함원식 | - |
dc.date.accessioned | 2015-04-24T16:26:25Z | - |
dc.date.available | 2015-04-24T16:26:25Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 2005-6737 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103515 | - |
dc.description.abstract | PURPOSE: We assessed the efficacy of radical prostatectomy (RP) in prostate cancer patients with preoperative prostate-specific antigen (PSA) levels > or = 20 ng/ml and no distant metastases. MATERIALS AND METHODS: The records of 132 prostate cancer patients undergoing RP with preoperative PSA levels > or =20 ng/ml and no distant metastases were reviewed. Sixty-six patients received preoperative neoadjuvant hormonal therapy. Pathologic and clinical outcomes were compared between the groups with PSA of 20-40 ng/ml and > or =40 ng/ml. RESULTS: There were no statistical differences in age, prostate volume, or the frequency of neoadjuvant hormonal therapy between the two groups. The PSA > or =40 ng/ml group had a higher RP Gleason score, tumor stage, and extracapsular extension. After a mean follow-up of 47.0 months, 73 (55.3%) patients had PSA progression with a median time of 37.0 months. Fifty-six patients received adjuvant hormonal therapy, and 19 received salvage external beam radiation therapy. Clinical disease progression developed in 10 patients (7.6%). During follow-up, 8 patients died, 1 of prostate cancer and 7 of other causes. Preoperative PSA was a significant predictor of PSA progression and time to PSA progression after RP, whereas there were no differences in distant metastasis, local recurrence, hormone-refractory prostate cancer progression, and overall or prostate cancer-specific death between the 2 groups. CONCLUSIONS: On the basis of the favorable postoperative outcomes of RP in patients with preoperative PSA > or =20 ng/ml and no distant metastases, we suggest that RP has a role in treating these high-risk prostate cancer patients and that preoperative PSA is a significant predictor of postoperative PSA progression | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 111~118 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF UROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 원격전이없이 술 전 Prostate-Specific Antigen (PSA) 20 ng/ml 이상인 전립선암 환자에서의 근치적 전립선적출술의 결과 | - |
dc.title.alternative | Outcome of Radical Prostatectomy in Prostate Cancer Patients with Prostate-Specific Antigen (PSA) Level Equal to or More Than 20 ng/ml and No Distant Metastasis Preoperatively | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨기과학) | - |
dc.contributor.googleauthor | 함원식 | - |
dc.contributor.googleauthor | 김상운 | - |
dc.contributor.googleauthor | 이주형 | - |
dc.contributor.googleauthor | 이진선 | - |
dc.contributor.googleauthor | 최영득 | - |
dc.identifier.doi | 10.4111/kju.2009.50.2.111 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04111 | - |
dc.contributor.localId | A04337 | - |
dc.relation.journalcode | J02134 | - |
dc.identifier.eissn | 2005-6745 | - |
dc.subject.keyword | Prostate-specific antigen | - |
dc.subject.keyword | Prostatic neoplasms | - |
dc.subject.keyword | Prostatectomy | - |
dc.subject.keyword | Treatment outcome | - |
dc.contributor.alternativeName | Choi, Young Deuk | - |
dc.contributor.alternativeName | Ham, Won Sik | - |
dc.contributor.affiliatedAuthor | Choi, Young Deuk | - |
dc.contributor.affiliatedAuthor | Ham, Won Sik | - |
dc.citation.volume | 50 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 111 | - |
dc.citation.endPage | 118 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF UROLOGY, Vol.50(2) : 111-118, 2009 | - |
dc.identifier.rimsid | 36057 | - |
dc.type.rims | ART | - |
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