Cited 17 times in
Retinol binding protein 4 and insulin resistance in apparently healthy elderly subjects
DC Field | Value | Language |
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dc.contributor.author | 심재용 | - |
dc.contributor.author | 이덕철 | - |
dc.contributor.author | 이지원 | - |
dc.contributor.author | 이혜리 | - |
dc.contributor.author | 박기덕 | - |
dc.date.accessioned | 2015-04-24T16:23:59Z | - |
dc.date.available | 2015-04-24T16:23:59Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0009-8981 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103442 | - |
dc.description.abstract | BACKGROUND: Insulin resistance (IR) increases with advancing age, yet the underlying mechanism is not well established. Although adipocytokine retinol binding protein 4 (RBP4) was recently shown to be linked to IR, their relationship remains controversial and relatively little information exists regarding their roles in the elderly subjects. We investigated the association between RBP4 and IR in obese and nonobese elderly subjects. METHODS: A total of 111 (68 nonobese and 43 obese) apparently healthy elderly subjects, aged 75.9+/-4.8 y were included. IR was determined by homeostasis model assessment (HOMA-IR). Serum RBP4 was measured by enzyme-linked immunosorbent assay. RESULTS: In all subjects, RBP4 levels were positively correlated with fasting insulin, HOMA-IR, and triglycerides. However, after subgroup analysis, RBP4 levels were positively correlated with fasting glucose, fasting insulin, and HOMA-IR in the obese group only. In step-wise multiple linear regression analysis, RBP4 was found to be independently associated with triglyceride levels in the nonobese group and independently associated with HOMA-IR in the obese group. CONCLUSIONS: The reason for the differing metabolic role of RBP4 in obese and nonobese elderly subjects remains uncertain, but our findings suggest that RBP4 may be linked to IR and lipid metabolism, at least in the elderly. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 30~32 | - |
dc.relation.isPartOf | CLINICA CHIMICA ACTA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Aging/blood | - |
dc.subject.MESH | Aging/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Health* | - |
dc.subject.MESH | Homeostasis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin Resistance* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Obesity/blood | - |
dc.subject.MESH | Obesity/pathology | - |
dc.subject.MESH | Obesity/physiopathology | - |
dc.subject.MESH | Retinol-Binding Proteins, Plasma/metabolism* | - |
dc.title | Retinol binding protein 4 and insulin resistance in apparently healthy elderly subjects | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Rehabilitation Medicine (재활의학) | - |
dc.contributor.googleauthor | Ji-Won Lee | - |
dc.contributor.googleauthor | Jee-Aee Im | - |
dc.contributor.googleauthor | Ki Deok Park | - |
dc.contributor.googleauthor | Hye-Ree Lee | - |
dc.contributor.googleauthor | Jae-Yong Shim | - |
dc.contributor.googleauthor | Duk-Chul Lee | - |
dc.identifier.doi | 10.1016/j.cca.2008.10.004 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02207 | - |
dc.contributor.localId | A02716 | - |
dc.contributor.localId | A01446 | - |
dc.contributor.localId | A03203 | - |
dc.contributor.localId | A03310 | - |
dc.relation.journalcode | J00543 | - |
dc.identifier.eissn | 1873-3492 | - |
dc.identifier.pmid | 18977339 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0009898108004841 | - |
dc.subject.keyword | Retinol binding protein-4 | - |
dc.subject.keyword | Insulin resistance | - |
dc.subject.keyword | Elderly | - |
dc.contributor.alternativeName | Shim, Jae Yong | - |
dc.contributor.alternativeName | Lee, Duk Chul | - |
dc.contributor.alternativeName | Lee, Ji Won | - |
dc.contributor.alternativeName | Lee, Hye Ree | - |
dc.contributor.alternativeName | Park, Ki Deok | - |
dc.contributor.affiliatedAuthor | Shim, Jae Yong | - |
dc.contributor.affiliatedAuthor | Lee, Duk Chul | - |
dc.contributor.affiliatedAuthor | Park, Ki Deok | - |
dc.contributor.affiliatedAuthor | Lee, Ji Won | - |
dc.contributor.affiliatedAuthor | Lee, Hye Ree | - |
dc.citation.volume | 400 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 30 | - |
dc.citation.endPage | 32 | - |
dc.identifier.bibliographicCitation | CLINICA CHIMICA ACTA, Vol.400(1-2) : 30-32, 2009 | - |
dc.identifier.rimsid | 37343 | - |
dc.type.rims | ART | - |
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