Cited 26 times in
Comparison of the validity of three biomarkers for gastric cancer screening: carcinoembryonic antigen, pepsinogens, and high sensitive C-reactive protein.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권오헌 | - |
dc.contributor.author | 송시영 | - |
dc.contributor.author | 임종백 | - |
dc.contributor.author | 정재복 | - |
dc.contributor.author | 정혜원 | - |
dc.date.accessioned | 2015-04-24T16:20:20Z | - |
dc.date.available | 2015-04-24T16:20:20Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0192-0790 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103345 | - |
dc.description.abstract | PURPOSE: To identify a desirable serum marker for screening tools for gastric cancer, we evaluated the validity of 3 biomarkers, namely, carcinoembryonic antigen (CEA), pepsinogens (PGs), and high sensitive C-reactive protein (hsCRP). METHODS: We estimated the mean serum levels of CEA, PGs, and hsCRP and compared the sensitivity and specificity of these 3 biomarkers in 378 subjects who were classified into 7 groups: normal, chronic atrophic gastritis, intestinal metaplasia, adenoma, early gastric cancer (EGC), advanced gastric cancer (AGC) without metastasis, and AGC with metastasis (M1). RESULTS: There were no significant differences among the normal, high-risk (chronic atrophic gastritis, intestinal metaplasia, and adenoma), and EGC groups for CEA and hsCRP. However, the levels of CEA were relatively higher in the AGC group with intestinal-type cancer (P<0.01). Likewise, hsCRP was relatively higher in the AGC group with diffuse-type cancer (P<0.01). For the PG I/II ratio, there was no significant difference among the normal, high-risk, and cancer groups, including EGC (P<0.01). In addition, there was a negative correlation with grades (gammas=-0.480, P<0.01). However, the PG I/II ratio was relatively less effective in diffuse-type cancer compared with intestinal-type cancer. The combination of serum hsCRP and the PG I/II ratio had a higher sensitivity (77%) than did the PG I/II ratio alone (61%) in diffuse-type cancers. CONCLUSIONS: The combination of serum hsCRP and PG I/II ratio would be helpful as a screening tool for gastric cancer in high incidence populations and may help to select high-risk subjects in need of further specific invasive screening tools such as endoscopy | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 19~26 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL GASTROENTEROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | C-Reactive Protein/metabolism* | - |
dc.subject.MESH | Carcinoembryonic Antigen/blood* | - |
dc.subject.MESH | Endoscopy, Gastrointestinal | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mass Screening/methods | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Metastasis | - |
dc.subject.MESH | Pepsinogens/blood* | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Stomach Neoplasms/blood | - |
dc.subject.MESH | Stomach Neoplasms/diagnosis* | - |
dc.subject.MESH | Stomach Neoplasms/pathology | - |
dc.title | Comparison of the validity of three biomarkers for gastric cancer screening: carcinoembryonic antigen, pepsinogens, and high sensitive C-reactive protein. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Hye Won Chung | - |
dc.contributor.googleauthor | Ju Won Kim | - |
dc.contributor.googleauthor | Jong-han Lee | - |
dc.contributor.googleauthor | Si Young Song | - |
dc.contributor.googleauthor | Jae Bock Chung | - |
dc.contributor.googleauthor | Oh Hun Kwon | - |
dc.contributor.googleauthor | Jong-Baeck Lim | - |
dc.identifier.doi | 10.1097/MCG.0b013e318135427c | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00237 | - |
dc.contributor.localId | A02035 | - |
dc.contributor.localId | A03403 | - |
dc.contributor.localId | A03706 | - |
dc.contributor.localId | A03781 | - |
dc.relation.journalcode | J01319 | - |
dc.identifier.eissn | 1539-2031 | - |
dc.identifier.pmid | 18648315 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00004836-200901000-00005&LSLINK=80&D=ovft | - |
dc.subject.keyword | gastric cancer | - |
dc.subject.keyword | CEA | - |
dc.subject.keyword | pepsinogens | - |
dc.subject.keyword | hsCRP | - |
dc.contributor.alternativeName | Kwon, Oh Hun | - |
dc.contributor.alternativeName | Song, Si Young | - |
dc.contributor.alternativeName | Lim, Jong Baeck | - |
dc.contributor.alternativeName | Chung, Jae Bock | - |
dc.contributor.alternativeName | Chung, Hye Won | - |
dc.contributor.affiliatedAuthor | Kwon, Oh Hun | - |
dc.contributor.affiliatedAuthor | Song, Si Young | - |
dc.contributor.affiliatedAuthor | Lim, Jong Baeck | - |
dc.contributor.affiliatedAuthor | Chung, Jae Bock | - |
dc.contributor.affiliatedAuthor | Chung, Hye Won | - |
dc.citation.volume | 43 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 19 | - |
dc.citation.endPage | 26 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL GASTROENTEROLOGY, Vol.43(1) : 19-26, 2009 | - |
dc.identifier.rimsid | 37285 | - |
dc.type.rims | ART | - |
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