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The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women
DC Field | Value | Language |
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dc.contributor.author | 김재훈 | - |
dc.date.accessioned | 2015-04-23T17:49:44Z | - |
dc.date.available | 2015-04-23T17:49:44Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0957-5243 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103212 | - |
dc.description.abstract | The purpose of the study was to investigate the association between cervical cancer risk and single-nucleotide polymorphisms (SNPs) in three one-carbon metabolism genes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) in Korean women. Twelve SNPs were identified in MTHFR, MTR, and MTRR in the 927 case-control samples, which included 165 cervical intraepithelial neoplasia 1 (CIN1), 167 cervical intraepithelial neoplasia 2 and 3 (CIN2/3), 155 cervical cancer patients, and 440 normal controls. The frequencies of the genotypes and haplotypes were assessed in the controls, CINs, and cervical cancers. Individual carriers of the variant allele C of MTHFR A1298C (rs1801131) had a 0.64-fold [95% confidence interval (CI): 0.42-0.98] decreased risk for CIN2/3 compared with common homozygotes. However, no significant association was found between most other variants and cervical cancer risk. The results also identified an increased CIN1 risk in carriers with at least one copy of haplotype 3 in the MTHFR gene (odds ratio, 1.88; 95% CI: 1.03-3.42). In conclusion, there was no significant association between most SNPs in MTHFR, MTR, or MTRR and the risk of CIN and cervical cancer in Korean women. In addition, there was no significant association of MTHFR haplotypes with risk of CIN2/3 and cervical cancer | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 23~30 | - |
dc.relation.isPartOf | CANCER CAUSES & CONTROL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/genetics* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cervical Intraepithelial Neoplasia/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Ferredoxin-NADP Reductase/genetics* | - |
dc.subject.MESH | Genetic Predisposition to Disease | - |
dc.subject.MESH | Haplotypes | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Methylenetetrahydrofolate Reductase (NADPH2)/genetics* | - |
dc.subject.MESH | Polymorphism, Genetic* | - |
dc.subject.MESH | Uterine Cervical Neoplasms/genetics* | - |
dc.title | The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | Seo-Yun Tong | - |
dc.contributor.googleauthor | Jong-Min Lee | - |
dc.contributor.googleauthor | Eun-Seop Song | - |
dc.contributor.googleauthor | Kwang-Beom Lee | - |
dc.contributor.googleauthor | Mi-Kyung Kim | - |
dc.contributor.googleauthor | Young Mi Yun | - |
dc.contributor.googleauthor | Jae-Kwan Lee | - |
dc.contributor.googleauthor | Sung-Kyong Son | - |
dc.contributor.googleauthor | Jung-Pil Lee | - |
dc.contributor.googleauthor | Jae-Hoon Kim | - |
dc.contributor.googleauthor | Soo-Young Hur | - |
dc.contributor.googleauthor | Yong-Il Kwon | - |
dc.identifier.doi | 10.1007/s10552-009-9430-z | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00876 | - |
dc.relation.journalcode | J03123 | - |
dc.identifier.eissn | 1573-7225 | - |
dc.identifier.pmid | 19760026 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs10552-009-9430-z | - |
dc.subject.keyword | Cervical intraepithelial neoplasia | - |
dc.subject.keyword | Cervical cancer | - |
dc.subject.keyword | Genetic polymorphisms | - |
dc.subject.keyword | Methylenetetrahydrofolate reductase | - |
dc.subject.keyword | Methionine synthase | - |
dc.subject.keyword | Methionine synthase reductase | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hoon | - |
dc.citation.volume | 21 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 23 | - |
dc.citation.endPage | 30 | - |
dc.identifier.bibliographicCitation | CANCER CAUSES & CONTROL, Vol.21(1) : 23-30, 2010 | - |
dc.identifier.rimsid | 35770 | - |
dc.type.rims | ART | - |
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