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지역 사회에 거주하는 건강한 노인 여성에서 한 계절에 측정한 비타민 D(25-hydroxyvitamin D) 및 DHEA-S와 우울증과의 상관 관계
DC Field | Value | Language |
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dc.contributor.author | 이덕철 | - |
dc.contributor.author | 이지연 | - |
dc.contributor.author | 정지연 | - |
dc.date.accessioned | 2015-04-23T17:45:37Z | - |
dc.date.available | 2015-04-23T17:45:37Z | - |
dc.date.issued | 2010 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/103078 | - |
dc.description.abstract | Background: Even some previous studies suggested that vitamin D deficiency may contribute to depressive disorder, the association between vitamin D deficiency and depression has been controversial. Furthermore, only few studies have done in general population. Dehydroepiandrosterone-sulfate (DHEA-S) is most abundant steroid hormone secreted by adrenal cortex, known to have diverse role in human includingstabilizing mood. Aim of this study was to investigate the association between serum 25-hydroxyvitmin D and DHEA-S and depression in community dwelling apparently healthy women. Methods: This study conducted as a part of the Yonsei Aging Study (YAS). YAS was designed as a survey to investigate the factors related to depression, cognitive function and physical performance in community dwelling old people in Korea. A total of 136 women aged older than 60 years. Blood sample is obtained in October and November in 2008. Depressive symptoms are assessed by self-reported by Geriatric depression scale-15 (GDS-15). Depressive disorder is defined as a GDS-15 score of 7 or higher. Cognitive abilities were assessed using the Mini-Mental State Examination (MMSE). Additionally, cardiometabolic risk factors, DHEA-S and 25-(OH) vitamin D level and physical performance index (by gait speed, chair stand test, and tandem standing test) were measured. Results: The prevalence of depression was vitamin D deficiency is 46.3% in this study population. Mean values of 25(OH) vitamin D and DHEA-S (18.47±7.10 ng/mL, 52.98±31.96 μg/dL respectively) in women with depression were lower than those in normal women (22.01±8.09 ng/mL, 44.58±32.54 μg/dL respectively; P<0.02, P=0.12 respectively). The prevalence of vitamin deficiency (25-hydroxy vitamin D <10 ng/mL) and vitamin insufficiency (25-hydroxy vitamin D <20 ng/mL) were 6.62% and 46.32% respectively. Correlation analysis showed GDS scores associated with 25-(OH) vitamin D level (r=−0.26, P<0.005), physical performance index (r=−0.22, P<0.01), and DHEA-S level (−0.20, P <0.05). Women with history of diabetes mellitus and current smoking habit had a higher prevalence of depression in statistical significance. A Multiple linear regression analysis showed that 25(OH) vitamin D level was an independent risk factor for depression after adjustment for confounding variables. Conclusion: This study suggested that 25-hydroxy vitamin D and DHEA-S levels are the independently associated with depression in apparently healthy community-dwelling older women. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 332~340 | - |
dc.relation.isPartOf | Korean Journal of Clinical Geriatrics (임상노인의학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 지역 사회에 거주하는 건강한 노인 여성에서 한 계절에 측정한 비타민 D(25-hydroxyvitamin D) 및 DHEA-S와 우울증과의 상관 관계 | - |
dc.title.alternative | Serum 25-hydroxyvitamin D and DHEA-S Level Are Associated with Depression in Community-dwelling Older Women: Surveyed in One Season | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학) | - |
dc.contributor.googleauthor | 김현미 | - |
dc.contributor.googleauthor | 이지연 | - |
dc.contributor.googleauthor | 정지연 | - |
dc.contributor.googleauthor | 이덕철 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02716 | - |
dc.contributor.localId | A03196 | - |
dc.contributor.localId | A03734 | - |
dc.relation.journalcode | J01981 | - |
dc.subject.keyword | 25-hydroxyvitamin D | - |
dc.subject.keyword | 25-OH-Vitamin D | - |
dc.subject.keyword | DHEA-S | - |
dc.subject.keyword | Dehydroepiandrosterone-sulfate | - |
dc.subject.keyword | Depressive disorder | - |
dc.subject.keyword | Depression | - |
dc.contributor.alternativeName | Lee, Duk Chul | - |
dc.contributor.alternativeName | Lee, Jee Yon | - |
dc.contributor.alternativeName | Chung, Ji Youn | - |
dc.contributor.affiliatedAuthor | Lee, Duk Chul | - |
dc.contributor.affiliatedAuthor | Lee, Jee Yon | - |
dc.contributor.affiliatedAuthor | Chung, Ji Youn | - |
dc.citation.volume | 11 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 332 | - |
dc.citation.endPage | 340 | - |
dc.identifier.bibliographicCitation | Korean Journal of Clinical Geriatrics (임상노인의학회지), Vol.11(4) : 332-340, 2010 | - |
dc.identifier.rimsid | 35670 | - |
dc.type.rims | ART | - |
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