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부갑상샘저하증과 거짓 부갑상샘저하증의 임상적 특성

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dc.contributor.author채현욱-
dc.contributor.author권아름-
dc.contributor.author김호성-
dc.date.accessioned2015-04-23T17:36:28Z-
dc.date.available2015-04-23T17:36:28Z-
dc.date.issued2010-
dc.identifier.issn1226-2242-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/102786-
dc.description.abstractPURPOSE: Insufficient production of the parathyroid hormone (PTH) by the parathyroid glands known as hypoparathyroidism, or a resistance against its action on target organs known as pseudohypoparathyroidism, cause PTH-related hypocalcemia associated with hyperphosphatemia. Signs and symptoms are caused by hypocalcemia. This study aimed to assess clinical characteristics, treatment, severity, onset time, and therapeutic responses of hypoparathyroidism and pseudohypoparathyroidism. METHODS: From January 2000 to February 2010, 21 hypoparathyroid and 10 pseudohypoparathyroid children were selected from Severance Hospital. Clinical manifestations and laboratory data were analyzed retrospectively. RESULTS: In hypoparathyroid patients, there were 14 with idiopathic hypothyroidism (66%) and 7 with 22q11.2 deletion syndrome (33%). Patients with hypoparathyroidism had more frequent neurologic symptoms compared to those with pseudohypoparathyroidism (2.89 +/- 1.75 vs. 1.25 +/- 1.67, P = 0.01). Required amounts of calcium to control hypocalcemia were larger in hypoparathyroidism than in pseudohypoparathyroidism (37.98 +/- 26.64 vs. 15.64 +/- 7.87 mg/day/kg, P = 0.034). After treatment, neurologic symptoms decreased significantly in hypoparathyroidism (P < 0.05) from 2.01 +/- 1.68 to 0.89 +/- 0.96. CONCLUSION: Hypoparathyroidism presented more severe symptoms than pseudohypoparathyroidism. Larger amounts of calcium were required to correct hypocalcemia in hypoparathyroidism than in pseudophypoparathyroidsm. These differences may be explained by the findings that distal tubules respond to PTH, in contrast to proximal tubules, in pseudohypoparathyroidism, because the GNAS gene coding is not imprinted at the distal tubular cells responsible for calcium reabsorption.-
dc.description.statementOfResponsibilityopen-
dc.format.extent181~186-
dc.relation.isPartOfJournal of Korean Society of Pediatric Endocrinology (대한소아내분비학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title부갑상샘저하증과 거짓 부갑상샘저하증의 임상적 특성-
dc.title.alternativeClinical Characteristics of Hypoparathyroidism and Pseudohypoparathyroidism-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthor이정헌-
dc.contributor.googleauthor채현욱-
dc.contributor.googleauthor권아름-
dc.contributor.googleauthor김덕희-
dc.contributor.googleauthor김호성-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04026-
dc.contributor.localIdA00228-
dc.contributor.localIdA01184-
dc.relation.journalcodeJ01548-
dc.subject.keywordHypoparathyroidism-
dc.subject.keywordPseudohypoparathyroidism-
dc.contributor.alternativeNameChae, Hyun Wook-
dc.contributor.alternativeNameKwon, Ah Reum-
dc.contributor.alternativeNameKim, Ho Seong-
dc.contributor.affiliatedAuthorChae, Hyun Wook-
dc.contributor.affiliatedAuthorKwon, Ah Reum-
dc.contributor.affiliatedAuthorKim, Ho Seong-
dc.citation.volume15-
dc.citation.number3-
dc.citation.startPage181-
dc.citation.endPage186-
dc.identifier.bibliographicCitationJournal of Korean Society of Pediatric Endocrinology (대한소아내분비학회지), Vol.15(3) : 181-186, 2010-
dc.identifier.rimsid56956-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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