Cited 8 times in
Mycobacterium tuberculosis-induced expression of Leukotactin-1 is mediated by the PI3-K/PDK1/Akt signaling pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조상래 | - |
dc.date.accessioned | 2015-04-23T17:09:58Z | - |
dc.date.available | 2015-04-23T17:09:58Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101945 | - |
dc.description.abstract | Chemokines function in the migration of circulating leukocytes to regions of inflammation, and have been implicated in chronic inflammatory conditions including mycobacterial infection. We investigated whether Leukotactin-1 (Lkn-1), a novel member of the CC-chemokines, is involved in the immune response of macrophages against Mycobacterium tuberculosis (MTB). In PMA-differentiated THP-1 cells, MTB infection increased mRNA expression of Lkn-1 in a dose-dependent manner. Lkn-1 induction peaked 12 h after infection, then declined gradually and returned to its basal level at 72 h. Secretion of Lkn-1 was elevated by MTB infection. The increase in expression and secretion of Lkn-1 caused by MTB was reduced in cells treated with inhibitors of phosphatidylinositol 3-kinase (PI3-K), 3-phosphoinositide-dependent kinase 1 (PDK1) and Akt. MTB-induced Akt phosphorylation was blocked by treatment with a PI3-K inhibitor or a PDK1 inhibitor, implying that PI3-K, PDK1, and Akt are associated with the signaling pathway that up-regulates Lkn-1 in response to MTB. These results suggest that Lkn-1 is novel member of the group of chemokines that is released by macrophages infected with MTB. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Chemokines, CC/genetics | - |
dc.subject.MESH | Chemokines, CC/immunology | - |
dc.subject.MESH | Chemokines, CC/metabolism* | - |
dc.subject.MESH | Chemotaxis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Macrophage Inflammatory Proteins/genetics | - |
dc.subject.MESH | Macrophage Inflammatory Proteins/immunology | - |
dc.subject.MESH | Macrophage Inflammatory Proteins/metabolism* | - |
dc.subject.MESH | Macrophages/drug effects | - |
dc.subject.MESH | Macrophages/immunology | - |
dc.subject.MESH | Macrophages/metabolism* | - |
dc.subject.MESH | Macrophages/microbiology | - |
dc.subject.MESH | Macrophages/pathology | - |
dc.subject.MESH | Mycobacterium tuberculosis/immunology* | - |
dc.subject.MESH | Mycobacterium tuberculosis/pathogenicity | - |
dc.subject.MESH | Oncogene Protein v-akt/metabolism | - |
dc.subject.MESH | Phosphatidylinositol 3-Kinases/metabolism | - |
dc.subject.MESH | Protein Kinase Inhibitors/pharmacology | - |
dc.subject.MESH | Protein-Serine-Threonine Kinases/metabolism | - |
dc.subject.MESH | Signal Transduction/drug effects | - |
dc.subject.MESH | Signal Transduction/immunology* | - |
dc.subject.MESH | Tuberculosis/genetics | - |
dc.subject.MESH | Tuberculosis/immunology* | - |
dc.subject.MESH | Tuberculosis/metabolism | - |
dc.title | Mycobacterium tuberculosis-induced expression of Leukotactin-1 is mediated by the PI3-K/PDK1/Akt signaling pathway | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Jang-Eun Cho | - |
dc.contributor.googleauthor | Yoon Suk Kim | - |
dc.contributor.googleauthor | Sangjung Park | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.contributor.googleauthor | Hyeyoung Lee | - |
dc.identifier.doi | 10.1007/s10059-010-0003-5 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03824 | - |
dc.contributor.localId | A04824 | - |
dc.relation.journalcode | J02273 | - |
dc.identifier.eissn | 0219-1032 | - |
dc.identifier.pmid | 20016943 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs10059-010-0003-5 | - |
dc.subject.keyword | 3-phosphoinositide-dependent kinase 1 | - |
dc.subject.keyword | Akt | - |
dc.subject.keyword | Leukotactin-1 | - |
dc.subject.keyword | Mycobacterium tuberculosis | - |
dc.subject.keyword | phosphatidylinositol 3-kinase | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Cho, Sang Nae | - |
dc.citation.volume | 29 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 35 | - |
dc.citation.endPage | 39 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, Vol.29(1) : 35-39, 2010 | - |
dc.identifier.rimsid | 50964 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.