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Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease
DC Field | Value | Language |
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dc.contributor.author | 방동식 | - |
dc.date.accessioned | 2015-04-23T17:06:19Z | - |
dc.date.available | 2015-04-23T17:06:19Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101829 | - |
dc.description.abstract | Behçet's disease is a genetically complex disease of unknown etiology characterized by recurrent inflammatory attacks affecting the orogenital mucosa, eyes and skin. We performed a genome-wide association study with 311,459 SNPs in 1,215 individuals with Behçet's disease (cases) and 1,278 healthy controls from Turkey. We confirmed the known association of Behçet's disease with HLA-B*51 and identified a second, independent association within the MHC Class I region. We also identified an association at IL10 (rs1518111, P = 1.88 x 10(-8)). Using a meta-analysis with an additional five cohorts from Turkey, the Middle East, Europe and Asia, comprising a total of 2,430 cases and 2,660 controls, we identified associations at IL10 (rs1518111, P = 3.54 x 10(-18), odds ratio = 1.45, 95% CI 1.34-1.58) and the IL23R-IL12RB2 locus (rs924080, P = 6.69 x 10(-9), OR = 1.28, 95% CI 1.18-1.39). The disease-associated IL10 variant (the rs1518111 A allele) was associated with diminished mRNA expression and low protein production. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | NATURE GENETICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Alleles | - |
dc.subject.MESH | Asia | - |
dc.subject.MESH | Behcet Syndrome/genetics* | - |
dc.subject.MESH | Behcet Syndrome/immunology | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Europe | - |
dc.subject.MESH | Genes, MHC Class I/genetics* | - |
dc.subject.MESH | Genome-Wide Association Study* | - |
dc.subject.MESH | HLA-B Antigens/genetics | - |
dc.subject.MESH | HLA-B Antigens/immunology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-10/genetics* | - |
dc.subject.MESH | Interleukin-10/immunology | - |
dc.subject.MESH | Middle East | - |
dc.subject.MESH | Polymorphism, Single Nucleotide | - |
dc.subject.MESH | Turkey | - |
dc.title | Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | Elaine F. Remmers | - |
dc.contributor.googleauthor | Fulya Cosan | - |
dc.contributor.googleauthor | Yohei Kirino | - |
dc.contributor.googleauthor | Michael J. Ombrello | - |
dc.contributor.googleauthor | Neslihan Abaci | - |
dc.contributor.googleauthor | Colleen Satorius | - |
dc.contributor.googleauthor | Julie M. Le | - |
dc.contributor.googleauthor | Barbara Yang | - |
dc.contributor.googleauthor | Benjamin D. Korman | - |
dc.contributor.googleauthor | Aris Cakiris | - |
dc.contributor.googleauthor | Oznur Aglar | - |
dc.contributor.googleauthor | Zeliha Emrence | - |
dc.contributor.googleauthor | Hulya Azakli | - |
dc.contributor.googleauthor | Duran Ustek | - |
dc.contributor.googleauthor | lknur Tugal-Tutkun | - |
dc.contributor.googleauthor | Gulsen Akman-Demir | - |
dc.contributor.googleauthor | Wei Chen | - |
dc.contributor.googleauthor | Christopher I. Amos | - |
dc.contributor.googleauthor | Michael B. Dizon | - |
dc.contributor.googleauthor | Afet Akdag Kose | - |
dc.contributor.googleauthor | Gulsevim Azizlerli | - |
dc.contributor.googleauthor | Burak Erer | - |
dc.contributor.googleauthor | Oliver J. Brand | - |
dc.contributor.googleauthor | Virginia G. Kaklamani | - |
dc.contributor.googleauthor | Phaedon Kaklamanis | - |
dc.contributor.googleauthor | Eldad Ben-Chetrit | - |
dc.contributor.googleauthor | Miles Stanford | - |
dc.contributor.googleauthor | Farida Fortune | - |
dc.contributor.googleauthor | Marwen Ghabra | - |
dc.contributor.googleauthor | William E. R. Ollier | - |
dc.contributor.googleauthor | Young-Hun Cho | - |
dc.contributor.googleauthor | Dongsik Bang | - |
dc.contributor.googleauthor | John O'Shea | - |
dc.contributor.googleauthor | Graham R. | - |
dc.contributor.googleauthor | Wallace | - |
dc.contributor.googleauthor | Massimo Gadina | - |
dc.contributor.googleauthor | Daniel L. Kastner | - |
dc.contributor.googleauthor | Ahmet Gül | - |
dc.identifier.doi | 10.1038/ng.625. | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01784 | - |
dc.relation.journalcode | J02294 | - |
dc.identifier.eissn | 1546-1718 | - |
dc.identifier.pmid | 20622878 | - |
dc.contributor.alternativeName | Bang, Dong Sik | - |
dc.contributor.affiliatedAuthor | Bang, Dong Sik | - |
dc.citation.volume | 42 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 698 | - |
dc.citation.endPage | 702 | - |
dc.identifier.bibliographicCitation | NATURE GENETICS, Vol.42(8) : 698-702, 2010 | - |
dc.identifier.rimsid | 54635 | - |
dc.type.rims | ART | - |
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