Cited 61 times in
Periodontal wound healing/regeneration following implantation of recombinant human growth/differentiation factor-5 in a beta-tricalcium phosphate carrier into one-wall intrabony defects in dogs.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김종관 | - |
dc.contributor.author | 이정석 | - |
dc.contributor.author | 정의원 | - |
dc.contributor.author | 최성호 | - |
dc.date.accessioned | 2015-04-23T16:39:29Z | - |
dc.date.available | 2015-04-23T16:39:29Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0303-6979 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100983 | - |
dc.description.abstract | OBJECTIVE: Recombinant human growth/differentiation factor-5 (rhGDF-5) is being evaluated as a candidate therapy in support of periodontal regeneration. The objective of this study was to evaluate periodontal wound healing/regeneration following the application of rhGDF-5 on a particulate beta-tricalcium phosphate (beta-TCP) carrier using an established defect model. MATERIALS AND METHODS: Bilateral 4 x 5 mm (width x depth), one-wall, critical-size, intrabony periodontal defects were surgically created at the mandibular second and fourth pre-molar teeth in 15 Beagle dogs. Unilateral defects in five animals received rhGDF-5/beta-TCP (Scil Technology GmbH); five animals received beta-TCP solo; and five animals served as sham-surgery controls. Contralateral sites received treatments reported elsewhere. The animals were sacrificed following an 8-week healing interval for histological examination. RESULTS: Clinical healing was generally uneventful. Sites implanted with rhGDF-5/beta-TCP exhibited greater enhanced cementum and bone formation compared with beta-TCP and sham-surgery controls; cementum regeneration averaged (+/- SD) 3.83 +/- 0.73 versus 1.65 +/- 0.82 and 2.48 +/- 1.28 mm for the controls (p<0.05). Corresponding values for bone regeneration height averaged 3.26 +/- 0.30 versus 1.70 +/- 0.66 and 1.68 +/- 0.49 mm (p<0.05), and bone area 10.45 +/- 2.26 versus 6.31 +/- 2.41 and 3.00 +/- 1.97 mm(2) (p<0.05). Cementum regeneration included cellular/acellular cementum with or without a functionally oriented periodontal ligament. A non-specific connective tissue attachment was evident in the sham-surgery control. Controls exhibited mostly woven bone with primary osteons, whereas rhGDF-5/beta-TCP sites showed a noticeable extent of lamellar bone. Sites receiving rhGDF-5/beta-TCP or beta-TCP showed some residual beta-TCP granules apparently undergoing biodegradation without obvious differences between the sites. Sites receiving beta-TCP alone commonly showed residual beta-TCP granules sequestered in the connective tissue or fibrovascular marrow. CONCLUSION: rhGDF-5/beta-TCP has a greater potential to support the regeneration of the periodontal attachment. Long-term studies are necessary to confirm the uneventful maturation of the regenerated tissues. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 382~389 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL PERIODONTOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Absorbable Implants* | - |
dc.subject.MESH | Alveolar Bone Loss/therapy | - |
dc.subject.MESH | Alveolar Process/drug effects | - |
dc.subject.MESH | Alveolar Process/physiology | - |
dc.subject.MESH | Alveolar Process/surgery | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Biocompatible Materials/administration & dosage | - |
dc.subject.MESH | Bone Regeneration/drug effects* | - |
dc.subject.MESH | Bone Regeneration/physiology | - |
dc.subject.MESH | Bone Substitutes/administration & dosage | - |
dc.subject.MESH | Calcium Phosphates/administration & dosage | - |
dc.subject.MESH | Dental Cementum/drug effects | - |
dc.subject.MESH | Dental Cementum/physiology | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Dogs | - |
dc.subject.MESH | Drug Carriers/administration & dosage | - |
dc.subject.MESH | Growth Differentiation Factor 5/administration & dosage | - |
dc.subject.MESH | Growth Differentiation Factor 5/physiology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mandible/drug effects | - |
dc.subject.MESH | Mandible/surgery | - |
dc.subject.MESH | Osseointegration/drug effects | - |
dc.subject.MESH | Osseointegration/physiology | - |
dc.subject.MESH | Periodontal Attachment Loss/drug therapy* | - |
dc.subject.MESH | Periodontal Ligament/drug effects | - |
dc.subject.MESH | Periodontal Ligament/physiology | - |
dc.subject.MESH | Periodontium/drug effects* | - |
dc.subject.MESH | Periodontium/physiology | - |
dc.subject.MESH | Recombinant Proteins | - |
dc.title | Periodontal wound healing/regeneration following implantation of recombinant human growth/differentiation factor-5 in a beta-tricalcium phosphate carrier into one-wall intrabony defects in dogs. | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Periodontology (치주과학) | - |
dc.contributor.googleauthor | Jung-Seok Lee | - |
dc.contributor.googleauthor | Ulf M. E. Wikesjö | - |
dc.contributor.googleauthor | Ui-Won Jung | - |
dc.contributor.googleauthor | Seong-Ho Choi | - |
dc.contributor.googleauthor | Susanne Pippig | - |
dc.contributor.googleauthor | Michael Siedler | - |
dc.contributor.googleauthor | Chong-Kwan Kim | - |
dc.identifier.doi | 10.1111/j.1600-051X.2010.01544.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03692 | - |
dc.contributor.localId | A03104 | - |
dc.contributor.localId | A04081 | - |
dc.contributor.localId | A00914 | - |
dc.relation.journalcode | J01337 | - |
dc.identifier.eissn | 1600-051X | - |
dc.identifier.pmid | 20447262 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1600-051X.2010.01544.x/abstract | - |
dc.subject.keyword | dog | - |
dc.subject.keyword | periodontal regeneration | - |
dc.subject.keyword | rhGDF‐5 | - |
dc.subject.keyword | tissue engineering | - |
dc.subject.keyword | β‐TCP | - |
dc.contributor.alternativeName | Kim, Chong Kwan | - |
dc.contributor.alternativeName | Lee, Jung Seok | - |
dc.contributor.alternativeName | Jung, Ui Won | - |
dc.contributor.alternativeName | Choi, Seong Ho | - |
dc.contributor.affiliatedAuthor | Jung, Ui Won | - |
dc.contributor.affiliatedAuthor | Lee, Jung Seok | - |
dc.contributor.affiliatedAuthor | Choi, Seong Ho | - |
dc.contributor.affiliatedAuthor | Kim, Chong Kwan | - |
dc.citation.volume | 37 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 382 | - |
dc.citation.endPage | 389 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL PERIODONTOLOGY, Vol.37(4) : 382-389, 2010 | - |
dc.identifier.rimsid | 54097 | - |
dc.type.rims | ART | - |
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