Cited 5 times in
Neuroprotective effects of mexiletine on motor evoked potentials in demyelinated rat spinal cords
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤도흠 | - |
dc.contributor.author | 이경희 | - |
dc.contributor.author | 이배환 | - |
dc.date.accessioned | 2015-04-23T16:36:29Z | - |
dc.date.available | 2015-04-23T16:36:29Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0168-0102 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100892 | - |
dc.description.abstract | This study was conducted to whether the administration of mexiletine, a Na+ channel blocker, impacts the recovery from demyelination. Under anesthesia, 0.1% ethidium bromide was injected into the dorsal funiculus (T3), followed by a mexiletine or saline treatment. Motor evoked potential (MEP) recordings and luxol fast blue stainings were performed at one, seven, 14, and 21 days post-operatively. Conduction was delayed during demyelination, but the mexiletine-injected group demonstrated shortened latencies and reductions in the demyelination area when compared to the control. These results suggest that systemic mexiletine plays a positive role in protecting neural tissues from demyelination. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 59~64 | - |
dc.relation.isPartOf | NEUROSCIENCE RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Arrhythmia Agents/pharmacology* | - |
dc.subject.MESH | Demyelinating Diseases/chemically induced | - |
dc.subject.MESH | Demyelinating Diseases/physiopathology* | - |
dc.subject.MESH | Ethidium | - |
dc.subject.MESH | Evoked Potentials, Motor/drug effects* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mexiletine/pharmacology* | - |
dc.subject.MESH | Neuroprotective Agents/pharmacology* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Sodium Channel Blockers/pharmacology* | - |
dc.subject.MESH | Spinal Cord/drug effects* | - |
dc.subject.MESH | Spinal Cord/physiopathology | - |
dc.subject.MESH | Spinal Cord Diseases/chemically induced | - |
dc.subject.MESH | Spinal Cord Diseases/physiopathology* | - |
dc.title | Neuroprotective effects of mexiletine on motor evoked potentials in demyelinated rat spinal cords | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | 정효일 | - |
dc.contributor.googleauthor | 박태선 | - |
dc.contributor.googleauthor | 이배환 | - |
dc.contributor.googleauthor | 윤성현 | - |
dc.contributor.googleauthor | 이우영 | - |
dc.contributor.googleauthor | 김왕배 | - |
dc.identifier.doi | 10.1016/j.neures.2010.01.004 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02546 | - |
dc.contributor.localId | A02791 | - |
dc.contributor.localId | A02662 | - |
dc.relation.journalcode | J02365 | - |
dc.identifier.eissn | 1872-8111 | - |
dc.identifier.pmid | 20096736 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0168010210000350 | - |
dc.subject.keyword | Mexiletine | - |
dc.subject.keyword | Motor evoked potentials | - |
dc.subject.keyword | Gliotoxin | - |
dc.subject.keyword | Demyelination | - |
dc.subject.keyword | Spinal cord | - |
dc.subject.keyword | Rat | - |
dc.contributor.alternativeName | Yoon, Do Heum | - |
dc.contributor.alternativeName | Lee, Kyung Hee | - |
dc.contributor.alternativeName | Lee, Bae Hwan | - |
dc.contributor.affiliatedAuthor | Yoon, Do Heum | - |
dc.contributor.affiliatedAuthor | Lee, Bae Hwan | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Hee | - |
dc.citation.volume | 67 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 59 | - |
dc.citation.endPage | 64 | - |
dc.identifier.bibliographicCitation | NEUROSCIENCE RESEARCH, Vol.67(1) : 59-64, 2010 | - |
dc.identifier.rimsid | 55288 | - |
dc.type.rims | ART | - |
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