Cited 28 times in
CC chemokines as potential immunologic markers correlated with clinical improvement of atopic dermatitis patients by immunotherapy
DC Field | Value | Language |
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dc.contributor.author | 오상호 | - |
dc.contributor.author | 이광훈 | - |
dc.contributor.author | 이민걸 | - |
dc.date.accessioned | 2015-04-23T16:35:54Z | - |
dc.date.available | 2015-04-23T16:35:54Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0906-6705 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100874 | - |
dc.description.abstract | Although immunotherapy is not accepted as a curative treatment for atopic dermatitis (AD), most studies have shown positive effects of immunotherapy on AD patients. The serum levels of CC chemokine ligand 17 (CCL17), CCL22 and CCL18 have been reported to be highly correlated with disease severity, which suggests important roles for CC chemokines in the pathogenesis of AD. OBJECTIVE: The purpose of this study was to investigate the changes in clinical and immunologic markers before and after immunotherapy and to find which CC chemokines correlate with clinical improvement after immunotherapy with house dust mite (HDM) allergens in AD patients. METHODS AND RESULTS: A total of 20 AD patients who were sensitized to HDM allergens through a skin-prick test and Pharmacia CAP system were treated with subcutaneous immunotherapy using HDM allergens (treatment duration 12-60 months). Eczema area and severity index scores in 20 patients with AD decreased significantly after immunotherapy (P < 0.001). Serum total immunoglobulin E (IgE) and Dermatophagoides pteronyssinus-specific IgE levels tended to decrease after treatment although this was not statistically significant, and the D. farinae-specific IgE level showed no change. Serum CCL17, CCL22 and CCL18 levels decreased significantly from baseline after treatment (P = 0.043, 0.017 and <0.001, respectively). The percentage reductions in serum CCL17 and CCL22 level were significantly correlated with reductions in disease severity (P = 0.007, R(2) = 0.301 and P = 0.037, R(2) = 0.177, respectively). CONCLUSION: We suggest that CCL17 and CCL22 are good immunological marker candidates that can be used to assess clinical improvement after immunotherapy in AD patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 246~251 | - |
dc.relation.isPartOf | EXPERIMENTAL DERMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antigens, Dermatophagoides/administration & dosage | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Chemokine CCL17/blood | - |
dc.subject.MESH | Chemokine CCL22/blood | - |
dc.subject.MESH | Chemokines, CC/blood* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Dermatitis, Atopic/immunology* | - |
dc.subject.MESH | Dermatitis, Atopic/pathology | - |
dc.subject.MESH | Dermatitis, Atopic/therapy* | - |
dc.subject.MESH | Dermatophagoides farinae/immunology | - |
dc.subject.MESH | Dermatophagoides pteronyssinus/immunology | - |
dc.subject.MESH | Desensitization, Immunologic | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulin E/blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Young Adult | - |
dc.title | CC chemokines as potential immunologic markers correlated with clinical improvement of atopic dermatitis patients by immunotherapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학) | - |
dc.contributor.googleauthor | Yeon Sook Kwon | - |
dc.contributor.googleauthor | Sang Ho Oh | - |
dc.contributor.googleauthor | Wen Hao Wu | - |
dc.contributor.googleauthor | Byung Gi Bae | - |
dc.contributor.googleauthor | Hee Jung Lee | - |
dc.contributor.googleauthor | Min-Geol Lee | - |
dc.contributor.googleauthor | Kwang Hoon Lee | - |
dc.identifier.doi | 10.1111/j.1600-0625.2009.00971.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02370 | - |
dc.contributor.localId | A02779 | - |
dc.contributor.localId | A02674 | - |
dc.relation.journalcode | J00866 | - |
dc.identifier.eissn | 1600-0625 | - |
dc.identifier.pmid | 19758316 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2009.00971.x/abstract | - |
dc.subject.keyword | atopic dermatitis | - |
dc.subject.keyword | CCL17 | - |
dc.subject.keyword | CCL18 | - |
dc.subject.keyword | CCL22 | - |
dc.subject.keyword | immunotherapy with house dust mites | - |
dc.contributor.alternativeName | Oh, Sang Ho | - |
dc.contributor.alternativeName | Lee, Kwang Hoon | - |
dc.contributor.alternativeName | Lee, Min Geol | - |
dc.contributor.affiliatedAuthor | Oh, Sang Ho | - |
dc.contributor.affiliatedAuthor | Lee, Min Geol | - |
dc.contributor.affiliatedAuthor | Lee, Kwang Hoon | - |
dc.citation.volume | 19 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 246 | - |
dc.citation.endPage | 251 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL DERMATOLOGY, Vol.19(3) : 246-251, 2010 | - |
dc.identifier.rimsid | 55276 | - |
dc.type.rims | ART | - |
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