Cited 503 times in
Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders
DC Field | Value | Language |
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dc.contributor.author | 황기철 | - |
dc.date.accessioned | 2015-04-23T16:25:58Z | - |
dc.date.available | 2015-04-23T16:25:58Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100571 | - |
dc.description.abstract | The beneficial effects of probiotics have been described in many diseases, but the mechanism by which they modulate the immune system is poorly understood. In this study, we identified a mixture of probiotics that up-regulates CD4(+)Foxp3(+) regulatory T cells (Tregs). Administration of the probiotics mixture induced both T-cell and B-cell hyporesponsiveness and down-regulated T helper (Th) 1, Th2, and Th17 cytokines without apoptosis induction. It also induced generation of CD4(+)Foxp3(+) Tregs from the CD4(+)CD25(-) population and increased the suppressor activity of naturally occurring CD4(+)CD25(+) Tregs. Conversion of T cells into Foxp3(+) Tregs is directly mediated by regulatory dendritic cells (rDCs) that express high levels of IL-10, TGF-beta, COX-2, and indoleamine 2,3-dioxygenase. Administration of probiotics had therapeutical effects in experimental inflammatory bowel disease, atopic dermatitis, and rheumatoid arthritis. The therapeutical effect of the probiotics is associated with enrichment of CD4(+)Foxp3(+) Tregs in the inflamed regions. Collectively, the administration of probiotics that enhance the generation of rDCs and Tregs represents an applicable treatment of inflammatory immune disorders. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2159~2164 | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adoptive Transfer | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Arthritis, Experimental/immunology | - |
dc.subject.MESH | Arthritis, Experimental/pathology | - |
dc.subject.MESH | Arthritis, Experimental/therapy | - |
dc.subject.MESH | CD11c Antigen/metabolism | - |
dc.subject.MESH | Dendritic Cells/immunology* | - |
dc.subject.MESH | Dendritic Cells/pathology | - |
dc.subject.MESH | Dermatitis, Atopic/immunology | - |
dc.subject.MESH | Dermatitis, Atopic/pathology | - |
dc.subject.MESH | Dermatitis, Atopic/therapy | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Forkhead Transcription Factors/metabolism* | - |
dc.subject.MESH | Immune System Diseases/immunology | - |
dc.subject.MESH | Immune System Diseases/pathology | - |
dc.subject.MESH | Immune System Diseases/therapy* | - |
dc.subject.MESH | Immunosuppression | - |
dc.subject.MESH | Inflammatory Bowel Diseases/immunology | - |
dc.subject.MESH | Inflammatory Bowel Diseases/pathology | - |
dc.subject.MESH | Inflammatory Bowel Diseases/therapy | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Mice, Transgenic | - |
dc.subject.MESH | Probiotics/administration & dosage* | - |
dc.subject.MESH | T-Lymphocytes, Regulatory/immunology* | - |
dc.subject.MESH | T-Lymphocytes, Regulatory/metabolism | - |
dc.subject.MESH | T-Lymphocytes, Regulatory/pathology | - |
dc.title | Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Life Science (의생명과학부) | - |
dc.contributor.googleauthor | Ho-Keun Kwon | - |
dc.contributor.googleauthor | Choong-Gu Lee | - |
dc.contributor.googleauthor | Jae-Seon So | - |
dc.contributor.googleauthor | Chang-Suk Chae | - |
dc.contributor.googleauthor | Ji-Sun Hwang | - |
dc.contributor.googleauthor | Anupama Sahoo | - |
dc.contributor.googleauthor | Jong Hee Nam | - |
dc.contributor.googleauthor | Joon Haeng Rhee | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.contributor.googleauthor | Sin-Hyeog Im | - |
dc.identifier.doi | 10.1073/pnas.0904055107 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04456 | - |
dc.relation.journalcode | J02550 | - |
dc.identifier.eissn | 1091-6490 | - |
dc.identifier.pmid | 20080669 | - |
dc.contributor.alternativeName | Hwang, Ki Chul | - |
dc.contributor.affiliatedAuthor | Hwang, Ki Chul | - |
dc.citation.volume | 107 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 2159 | - |
dc.citation.endPage | 2164 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol.107(5) : 2159-2164, 2010 | - |
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