Cited 2 times in
An age-related decline of CD62L and vaccine response: a role of microRNA 92a?
DC Field | Value | Language |
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dc.contributor.author | 신재일 | - |
dc.date.accessioned | 2015-01-06T17:31:22Z | - |
dc.date.available | 2015-01-06T17:31:22Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2164-5515 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/100136 | - |
dc.description.abstract | Aging process can affect T cell and antibody response to vaccination and an age-related decline in the expression of CD62L on CD8+ T-lymphocyte is one of the important factors that contribute. A recent report demonstrated that percentage of CD3+CD8+CD62L+ cells and CD8+ T-lymphocyte microRNA-92a levels significantly decline with the age and were positively correlated. These results suggested that the age-related attrition of human naïve T cells could be connected to a reduced microRNA-92a in T-lymphocytes and downregulation of the microRNA-92a level might indicate exhaustion of naïve T-cells due to alteration of the immunologic condition with aging. Further studies are necessary to evaluate whether targeting microRNA-92a as microRNA mimics could be one of the therapeutic strategies in improving vaccine response in elderly. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1404~1405 | - |
dc.relation.isPartOf | HUMAN VACCINES & IMMUNOTHERAPEUTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aging/immunology* | - |
dc.subject.MESH | CD4-Positive T-Lymphocytes/immunology* | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes/immunology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hepatitis B Antibodies/blood* | - |
dc.subject.MESH | Hepatitis B Surface Antigens/immunology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | L-Selectin/physiology* | - |
dc.subject.MESH | Male | - |
dc.title | An age-related decline of CD62L and vaccine response: a role of microRNA 92a? | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Jae Il Shin | - |
dc.contributor.googleauthor | Jagadeesh Bayry | - |
dc.identifier.doi | 10.4161/hv.27665 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02142 | - |
dc.relation.journalcode | J01014 | - |
dc.identifier.eissn | 2164-554X | - |
dc.identifier.pmid | 24401614 | - |
dc.identifier.url | http://www.tandfonline.com/doi/abs/10.4161/hv.27665?journalCode=khvi20#.VIpQedKsXTo | - |
dc.subject.keyword | CD62L | - |
dc.subject.keyword | CD8+ T-lymphocyte | - |
dc.subject.keyword | immunosenescence | - |
dc.subject.keyword | microRNA 92a | - |
dc.subject.keyword | vaccine response | - |
dc.contributor.alternativeName | Shin, Jae Il | - |
dc.contributor.affiliatedAuthor | Shin, Jae Il | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 10 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1404 | - |
dc.citation.endPage | 1405 | - |
dc.identifier.bibliographicCitation | HUMAN VACCINES & IMMUNOTHERAPEUTICS, Vol.10(5) : 1404-1405, 2014 | - |
dc.identifier.rimsid | 50534 | - |
dc.type.rims | ART | - |
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